Molecular structure of NU 6140, CAS Number: 444723-13-1
NU 6140 (CAS 444723-13-1)
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Alternate Names:
4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide; Cdk2 Inhibitor IV
Application:
NU 6140 is a highly cell-permeable purine compound that acts a ATP-competitive inhibitor of Cdks
CAS Number:
444723-13-1
Purity:
≥95%
Molecular Weight:
422.52
Molecular Formula:
C23H30N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cdk2 Inhibitor IV, NU6140 is a highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Cdk2 Inhibitor IV, NU6140 has been shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Cdk2 Inhibitor IV, NU6140 has also been shown to synergistically potentiate paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
NU 6140 (CAS 444723-13-1) References
- Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. | Pennati, M., et al. 2005. Mol Cancer Ther. 4: 1328-37. PMID: 16170024
- Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. | Verhelle, D., et al. 2007. Cancer Res. 67: 746-55. PMID: 17234786
- Cyclin-dependent kinase 2 controls peripheral immune tolerance. | Chunder, N., et al. 2012. J Immunol. 189: 5659-66. PMID: 23136201
- Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. | Bhattacharya, S., et al. 2014. Apoptosis. 19: 451-66. PMID: 24242917
- Assessment of the Potential of CDK2 Inhibitor NU6140 to Influence the Expression of Pluripotency Markers NANOG, OCT4, and SOX2 in 2102Ep and H9 Cells. | Kallas, A., et al. 2014. Int J Cell Biol. 2014: 280638. PMID: 25477962
- Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression. | Boekhout, M., et al. 2016. EMBO Rep. 17: 414-27. PMID: 26882548
- Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. | Zhang, Y., et al. 2016. Cell Stem Cell. 18: 368-81. PMID: 26942852
- Silencing of CDK2, but not CDK1, separates mitogenic from anti-apoptotic signaling, sensitizing p53 defective cells for synthetic lethality. | Nekova, TS., et al. 2016. Cell Cycle. 15: 3203-3209. PMID: 27831832
- Residual Cdk1/2 activity after DNA damage promotes senescence. | Müllers, E., et al. 2017. Aging Cell. 16: 575-584. PMID: 28345297
- Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation. | Liao, R. and Mizzen, CA. 2017. Epigenetics Chromatin. 10: 29. PMID: 28539972
- Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair. | Tempka, D., et al. 2018. Redox Biol. 15: 316-326. PMID: 29306194
- Cyclin-dependent kinase control of motile ciliogenesis. | Vladar, EK., et al. 2018. Elife. 7: PMID: 30152757
- Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. | McNally, R., et al. 2019. ACS Chem Biol. 14: 587-593. PMID: 30763067
- RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells. | Shin, G., et al. 2019. J Biol Chem. 294: 16255-16265. PMID: 31519754
- Structural and binding studies of cyclin-dependent kinase 2 with NU6140 inhibitor. | Talapati, SR., et al. 2021. Chem Biol Drug Des. 98: 857-868. PMID: 34423559
Inhibitor of:
Cdc2, Cdk2, Cdk4, Cdk5, Cdk7, Cdx2, Clb2, LRRIQ1, Peregrin, PPAN, String, V1RG1, and YAP.Activator of:
Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NU 6140, 5 mg | sc-202531 | 5 mg | $147.00 |