Date published: 2025-10-16

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nTZDpa (CAS 118414-59-8)

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Application:
nTZDpa is a non-thiazolidinedione PPARγ partial agonist
CAS Number:
118414-59-8
Purity:
≥98%
Molecular Weight:
428.33
Molecular Formula:
C22H15Cl2NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist; with ~25% maximum efficacy. nTZDpa antagonizes full agonist activity by ~60%. Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. nTZDpa modulates metabolism and insulin sensitivity.


nTZDpa (CAS 118414-59-8) References

  1. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.  |  Berger, JP., et al. 2003. Mol Endocrinol. 17: 662-76. PMID: 12554792
  2. Antimicrobial activity of the membrane-active compound nTZDpa is enhanced at low pH.  |  Kim, SM., et al. 2022. Biomed Pharmacother. 150: 112977. PMID: 35447554
  3. L007-0069 kills Staphylococcus aureus in high resistant phenotypes.  |  Pengfei, S., et al. 2022. Cell Mol Life Sci. 79: 552. PMID: 36244019
  4. PPAR-γ Partial Agonists in Disease-Fate Decision with Special Reference to Cancer.  |  Ballav, S., et al. 2022. Cells. 11: PMID: 36291082
  5. Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of Syzygium polyanthum (Wight.)'s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model.  |  Widyawati, T., et al. 2022. Molecules. 27: PMID: 36296407
  6. A structural mechanism of nuclear receptor biased agonism.  |  Nemetchek, MD., et al. 2022. Proc Natl Acad Sci U S A. 119: e2215333119. PMID: 36469765

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

nTZDpa, 10 mg

sc-204140
10 mg
$148.00

nTZDpa, 50 mg

sc-204140A
50 mg
$658.00