NT5DC1 Antibody (B-3): sc-398165
- NT5DC1 Antibody (B-3) is a mouse monoclonal IgG2b κ NT5DC1 antibody provided at 200 µg/ml
- raised against amino acids 277-364 mapping within an internal region of NT5DC1 of human origin
- NT5DC1 Antibody (B-3) is recommended for detection of NT5DC1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NT5DC1 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NT5DC1 Antibody (B-3) for WB applications. These reagents are now offered in bundles with NT5DC1 Antibody (B-3) (see ordering information below).
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NT5DC1 Antibody (B-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects NT5DC1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NT5DC1 (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NT5DC1, also known as 5′-nucleotidase domain-containing protein 1, consists of 455 amino acids and is a member of the 5′(3′)-deoxyribonucleotidase family, playing a crucial role in nucleotide metabolism by catalyzing the hydrolysis of nucleotides to nucleosides and inorganic phosphate. This enzymatic activity is vital for maintaining cellular nucleotide pools, which are essential for DNA and RNA synthesis, thus influencing cell proliferation and survival. The gene encoding NT5DC1 is located on human chromosome 6q22.1, a region that is significant not only for its involvement in various genetic disorders but also for its association with cancer susceptibility, as deletions in this area have been linked to early onset intestinal cancer. Understanding NT5DC1 function and role in nucleotide metabolism can provide insights into therapeutic targets for diseases related to nucleotide imbalances, including certain cancers and metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NT5DC1 Antibody (B-3) References:
- Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. | Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
- COL11A2 mutation associated with autosomal recessive Weissenbacher-Zweymuller syndrome: molecular and clinical overlap with otospondylomegaepiphyseal dysplasia (OSMED). | Harel, T., et al. 2005. Am J Med Genet A. 132A: 33-5. PMID: 15558753
- Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22. | Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
- Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. | Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
- Associations among behavior-related susceptibility factors in porphyria cutanea tarda. | Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
- A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene. | Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NT5DC1 Antibody (B-3) | sc-398165 | 200 µg/ml | $322.00 | |||
NT5DC1 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-524240 | 200 µg Ab, 40 µg BP | $361.00 | |||
NT5DC1 Antibody (B-3): m-IgG2b BP-HRP Bundle | sc-549155 | 200 µg Ab; 10 µg BP | $361.00 | |||
NT5DC1 Antibody (B-3) AC | sc-398165 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NT5DC1 Antibody (B-3) HRP | sc-398165 HRP | 200 µg/ml | $322.00 | |||
NT5DC1 Antibody (B-3) FITC | sc-398165 FITC | 200 µg/ml | $336.00 | |||
NT5DC1 Antibody (B-3) PE | sc-398165 PE | 200 µg/ml | $349.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 488 | sc-398165 AF488 | 200 µg/ml | $364.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 546 | sc-398165 AF546 | 200 µg/ml | $364.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 594 | sc-398165 AF594 | 200 µg/ml | $364.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 647 | sc-398165 AF647 | 200 µg/ml | $364.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 680 | sc-398165 AF680 | 200 µg/ml | $364.00 | |||
NT5DC1 Antibody (B-3) Alexa Fluor® 790 | sc-398165 AF790 | 200 µg/ml | $364.00 |