NT-4 Antibody (C-1): sc-365444
- NT-4 Antibody (C-1) is a mouse monoclonal IgG1 κ NT-4 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 77-103 within an internal region of NT-4 of human origin
- NT-4 Antibody (C-1) is recommended for detection of NT-4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-NT-4 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NT-4 Antibody (C-1). This work is in progress.
NT-4 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects NT-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NT-4 Antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NT-4 protein plays a crucial role in the nervous system by promoting the survival and differentiation of specific neuronal populations, particularly during development. NT-4 is part of the neurotrophin family, which includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). These neurotrophins interact with specific receptors on the surface of neurons, such as Trk A, Trk B, and Trk C receptors, to mediate their effects. NT-4′s ability to bind to Trk B receptor, which is also responsive to BDNF, highlights NT-4′s significance in neuronal health and plasticity. Understanding NT-4 interactions and functions is essential for elucidating mechanisms underlying neuronal survival and potential therapeutic applications in neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NT-4 Antibody (C-1) References:
- Neurotrophin receptors: a window into neuronal differentiation. | Chao, MV. 1992. Neuron. 9: 583-93. PMID: 1327010
- The changing scene of neurotrophic factors. | Thoenen, H. 1991. Trends Neurosci. 14: 165-70. PMID: 1713715
- Cell death during development of the nervous system. | Oppenheim, RW. 1991. Annu Rev Neurosci. 14: 453-501. PMID: 2031577
- NT-4/5 antagonizes the BDNF modulation of corticostriatal transmission: Role of the TrkB.T1 receptor. | Torres-Cruz, FM., et al. 2019. CNS Neurosci Ther. 25: 621-631. PMID: 30666798
- NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats. | Wang, T., et al. 2020. J Neuroinflammation. 17: 158. PMID: 32416727
- The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review. | Ribeiro, D., et al. 2021. Int J Mol Sci. 22: PMID: 34445512
- Neuroprotective effects of pre-ischemic exercise are linked to expression of NT-3/NT-4 and TrkB/TrkC in rats. | Moghanlou, AE., et al. 2023. Brain Res Bull. 194: 54-63. PMID: 36646145
- Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex. | Antonini, A., et al. 2023. bioRxiv.. PMID: 38187745
- Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. | Ip, NY., et al. 1993. Neuron. 10: 137-49. PMID: 7679912
- Role of neurotrophins in mouse neuronal development. | Klein, R. 1994. FASEB J. 8: 738-44. PMID: 8050673
- The conservation of neurotrophic factors during vertebrate evolution. | Götz, R. and Schartl, M. 1994. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 108: 1-10. PMID: 8061955
- The neurotrophic factor concept: a reexamination. | Korsching, S. 1993. J Neurosci. 13: 2739-48. PMID: 8331370
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NT-4 Antibody (C-1) | sc-365444 | 200 µg/ml | $322.00 | |||
NT-4 Antibody (C-1) AC | sc-365444 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NT-4 Antibody (C-1) HRP | sc-365444 HRP | 200 µg/ml | $322.00 | |||
NT-4 Antibody (C-1) FITC | sc-365444 FITC | 200 µg/ml | $336.00 | |||
NT-4 Antibody (C-1) PE | sc-365444 PE | 200 µg/ml | $349.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 488 | sc-365444 AF488 | 200 µg/ml | $364.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 546 | sc-365444 AF546 | 200 µg/ml | $364.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 594 | sc-365444 AF594 | 200 µg/ml | $364.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 647 | sc-365444 AF647 | 200 µg/ml | $364.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 680 | sc-365444 AF680 | 200 µg/ml | $364.00 | |||
NT-4 Antibody (C-1) Alexa Fluor® 790 | sc-365444 AF790 | 200 µg/ml | $364.00 | |||
NT-4 (C-1) Neutralizing Peptide | sc-365444 P | 100 µg/0.5 ml | $69.00 |