NSF Antibody (G-7): sc-514949
- NSF Antibody (G-7) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 49-71 near the N-terminus of NSF of human origin
- recommended for detection of NSF of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NSF Antibody (G-7). This work is in progress.
QUICK LINKS
SEE ALSO...
NSF Antibody (G-7) is a mouse monoclonal IgM antibody that detects NSF in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NSF, or N-ethylmaleimide-sensitive factor, plays a crucial role in the process of membrane fusion, which is essential for various cellular functions, including neurotransmitter release and vesicle trafficking. NSF is primarily located in the cytoplasm, where NSF interacts with soluble NSF attachment proteins (SNAPs) and syntaxins to facilitate the assembly of the SNARE complex, a key component in the exocytosis pathway. NSF (G-7) antibody provides a reliable tool for researchers aiming to explore the dynamics of membrane fusion and its implications in health and disease. Proper functioning of NSF is vital for maintaining synaptic transmission and cellular communication, as NSF ensures that vesicles fuse with their target membranes at the right time and location. Disruptions in NSF activity can lead to significant cellular dysfunction and are implicated in various neurological disorders, highlighting the importance of studying NSF in both basic and clinical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NSF Antibody (G-7) References:
- N-ethylmaleimide sensitive factor (NSF) structure and function. | Whiteheart, SW., et al. 2001. Int Rev Cytol. 207: 71-112. PMID: 11352269
- Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF). | Zhao, C., et al. 2012. Biochim Biophys Acta. 1823: 159-71. PMID: 21689688
- Potential cellular functions of N-ethylmaleimide sensitive factor in the photoreceptor. | Huang, SP. and Craft, CM. 2012. Adv Exp Med Biol. 723: 791-7. PMID: 22183408
- The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. | Li, T., et al. 2015. J Biol Chem. 290: 17656-17667. PMID: 25953899
- The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. | Gokhale, A., et al. 2015. J Neurosci. 35: 7643-53. PMID: 25972187
- N-ethylmaleimide-sensitive factor siRNA improves cardiac function following myocardial infarction in rats. | Zhou, Y., et al. 2015. Genet Mol Res. 14: 9478-85. PMID: 26345881
- Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). | Zhao, M. and Brunger, AT. 2016. J Mol Biol. 428: 1912-26. PMID: 26546278
- N-ethylmaleimide‑sensitive factor siRNA inhibits the release of Weibel-Palade bodies in endothelial cells. | Zhou, Y., et al. 2016. Mol Med Rep. 14: 1061-6. PMID: 27277949
- Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation. | Yang, Y., et al. 2018. Front Immunol. 9: 725. PMID: 29696021
- N-ethylmaleimide-sensitive factor elicits a neuroprotection against ischemic neuronal injury by restoring autophagic/lysosomal dysfunction. | Qiu, M., et al. 2024. Cell Death Discov. 10: 368. PMID: 39155286
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSF Antibody (G-7) | sc-514949 | 200 µg/ml | $322.00 | |||
NSF (G-7) Neutralizing Peptide | sc-514949 P | 100 µg/0.5 ml | $69.00 |