Molecular structure of NSC 95397, CAS Number: 93718-83-3
NSC 95397 (CAS 93718-83-3)
See product citations (9)
Alternate Names:
2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Application:
NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor
CAS Number:
93718-83-3
Purity:
>97%
Molecular Weight:
310.38
Molecular Formula:
C14H14O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor. The compound has been reported to inhibit Cdc25A, B and C, and is more selective than VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b. Cdc25A is a phosphatase vital for the progression of the cell cycle and NSC 95397 has been noted to inhibit the G2/M phase transition and cell growth. NSC 95397 has demonstrated the ability to activate ERK-1 and ERK-2, induce tyrosine phosphorylation of EGFR, activate caspase-3, and inhibit MKP-1 and MKP-3.
NSC 95397 (CAS 93718-83-3) References
- Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. | Lazo, JS., et al. 2002. Mol Pharmacol. 61: 720-8. PMID: 11901209
- Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells. | Nemoto, K., et al. 2004. Prostate. 58: 95-102. PMID: 14673957
- NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. | Han, Y., et al. 2004. J Pharmacol Exp Ther. 309: 64-70. PMID: 14718602
- Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. | Melchheier, I., et al. 2005. Biochem Biophys Res Commun. 327: 1016-23. PMID: 15652497
- Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties. | Peyregne, VP., et al. 2005. Mol Cancer Ther. 4: 595-602. PMID: 15827333
- Fluorinated NSC as a Cdc25 inhibitor. | Park, H., et al. 2007. Bioorg Med Chem Lett. 17: 2351-4. PMID: 17379514
- A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. | Vogt, A., et al. 2008. Mol Cancer Ther. 7: 330-40. PMID: 18245669
- Nanosecond molecular dynamics simulations of Cdc25B and its complex with a 1,4-naphthoquinone inhibitor: implications for rational inhibitor design. | Ko, S., et al. 2008. J Mol Graph Model. 27: 13-9. PMID: 18359256
- Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines. | Larsson, DE., et al. 2009. Cancer Chemother Pharmacol. 65: 5-12. PMID: 19381631
- The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro. | Larsson, DE., et al. 2010. Anticancer Res. 30: 149-56. PMID: 20150630
- Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases. | Yang, Y., et al. 2014. Biochem Pharmacol. 88: 201-15. PMID: 24468133
- Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. | Blevins, MA., et al. 2015. J Biomol Screen. 20: 663-72. PMID: 25477201
- Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397. | Jemaà, M., et al. 2016. Cell Physiol Biochem. 40: 597-607. PMID: 27889774
- NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. | Dubey, NK., et al. 2018. Int J Mol Sci. 19: PMID: 29857489
- Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway. | Wei, YY., et al. 2021. Phytomedicine. 92: 153743. PMID: 34583225
Inhibitor of:
Cdc25, Cdc25B, Cdc25C, CTDSPL, CTDSPL2, DUSP, DUSP (Dual specificity protein phosphatase), DUSP22, ISG15, MKP-1, MKP-2, MKP-3, PAC-1, PADI2, PADI3, PADI6, PHPT1, Radixin, S-100A10, TSG-6, USP25, ZNF682, ZNF701, and ZNF708.Activator of:
caspase-3, and PIAS 3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 95397, 10 mg | sc-203654 | 10 mg | $255.00 | |||
| US: Only available in the US | ||||||
NSC 95397, 50 mg | sc-203654A | 50 mg | $847.00 | |||
| US: Only available in the US | ||||||