Molecular structure of NSC 87877, CAS Number: 56990-57-9
NSC 87877 (CAS 56990-57-9)
See product citations (12)
Alternate Names:
8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic Acid
Application:
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases
CAS Number:
56990-57-9
Purity:
>98%
Molecular Weight:
459.45
Molecular Formula:
C19H13N3O7S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1). IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 muM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR, respectively. NSC 87877 has also been shown to inhibit EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability and/or proliferation.
NSC 87877 (CAS 56990-57-9) References
- Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. | Chen, L., et al. 2006. Mol Pharmacol. 70: 562-70. PMID: 16717135
- Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. | Zhao, XT., et al. 2007. Dev Neurobiol. 67: 1789-801. PMID: 17659592
- hTRPC1-associated alpha-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. | Redondo, PC., et al. 2007. J Thromb Haemost. 5: 2476-83. PMID: 17892531
- NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). | Song, M., et al. 2009. Biochem Biophys Res Commun. 381: 491-5. PMID: 19233143
- Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. | Stephan, MT., et al. 2012. Biomaterials. 33: 5776-87. PMID: 22594972
- Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. | Luo, Q., et al. 2014. Br J Pharmacol. 171: 1706-21. PMID: 24372081
- NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. | Shi, Y., et al. 2015. Cell Death Dis. 6: e1841. PMID: 26247726
- Off-target inhibition by active site-targeting SHP2 inhibitors. | Tsutsumi, R., et al. 2018. FEBS Open Bio. 8: 1405-1411. PMID: 30186742
- Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Facilitates CD31hiEndomucinhi Blood Vessel and Bone Formation in Ovariectomized Mice. | Yin, H., et al. 2018. Cell Physiol Biochem. 50: 1068-1083. PMID: 30355920
- SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody. | Huda, S., et al. 2020. Neurol Neuroimmunol Neuroinflamm. 7: PMID: 31831571
- Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke. | Wu, Z., et al. 2022. Front Genet. 13: 833545. PMID: 35401659
- SHP2 inhibition enhances Yes-associated protein-mediated liver regeneration in murine partial hepatectomy models. | Watkins, RD., et al. 2022. JCI Insight. 7: PMID: 35763355
- Immune depletion of the methylated phenotype of colon cancer is closely related to resistance to immune checkpoint inhibitors. | Zhong, C., et al. 2022. Front Immunol. 13: 983636. PMID: 36159794
Inhibitor of:
ALP, CTDSPL2, Cytokeratin 14, DEP-1, Fap-1, HAPLN3, HD-PTP, HePTP, INPP5J, Integrin αVIa, LAIR-1, MIPP, P-Rex1, PPEF-2, PRL-1, PRL-3, Protein tyrosine phosphatase receptor (PTPR), PTP beta, PTPδ, PTPγ, PTPψ, PTP1B, PTP22, PTPDC1, PTPN21, PTPRCAP, PTPS, SH-PTP1, SH-PTP2, SHIP-2, SHP, SIAH-1, SIRP-β1b, SSH2, TC-PTP, Type I 4-phosphatase, and Vav.Activator of:
ADAM6A, ADAM6B, Cypt3, Dab2, DUSP12, DUSP26, GLB1L2, Ott, PTEN, PTP 1β, RPTPα, SH-PTP2, and SHIP-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 87877, 50 mg | sc-204139 | 50 mg | $134.00 |