Molecular structure of NSC 632839 hydrochloride, CAS Number: 157654-67-6
NSC 632839 hydrochloride (CAS 157654-67-6)
Alternate Names:
3,5-Bis[(4-methylphenyl)methylene]- 4-piperidone hydrochloride
Application:
NSC 632839 hydrochloride is an inhibitor of ubiquitin isopeptidase activity
CAS Number:
157654-67-6
Purity:
≥99%
Molecular Weight:
339.86
Molecular Formula:
C21H21NO.HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
NSC 632839 hydrochloride is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.
NSC 632839 hydrochloride (CAS 157654-67-6) References
- Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. | Aleo, E., et al. 2006. Cancer Res. 66: 9235-44. PMID: 16982768
- HIF-1α downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic mammalian orthoreovirus. | Gupta-Saraf, P. and Miller, CL. 2014. Oncotarget. 5: 561-74. PMID: 24504474
- CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. | Zeng, M., et al. 2016. Nat Commun. 7: 11364. PMID: 27098497
Inhibitor of:
3BP2, CCP6, COL2A1, DDI1, EG368203, OTUB2, OTUD3, OTUD5, PLIC-1, Protease, RACK1, RMND5A, UBC, UCH-L4, USP, USP1, USP24, USP27X, USP35, USP36, USP38, USP4, USP47, USP6, and USP9X.Activator of:
AOS-1, frizzled-4, USP17L29, USP2, USP3, and USP48.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 632839 hydrochloride, 10 mg | sc-204138 | 10 mg | $119.00 | |||
NSC 632839 hydrochloride, 50 mg | sc-204138A | 50 mg | $465.00 |