Molecular structure of NSC 295642, CAS Number: 77111-29-6
NSC 295642 (CAS 77111-29-6)
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Alternate Names:
Bis-[chloro[phenylmethyl [1-(2-pyridinyl)ethylidene]hydrazinecarbodithioato-N2,N2′,S1′]-copper]
CAS Number:
77111-29-6
Molecular Weight:
399.42
Molecular Formula:
C15H14ClCuN3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC 295642, referred to as Bis-[chloro[phenylmethyl [1-(2-pyridinyl)ethylidene]hydrazinecarbodithioato-N2,N2′,S1′]-copper], is a highly effective compound that inhibits cell migration, making it an important tool for scientific investigations. In addition to its role as a cell migration inhibitor, NSC 295642 also acts as a potent phosphatase inhibitor. It has been observed to significantly enhance cytonuclear differences of phospho-Erk in intact cells. As a result, NSC 295642 holds great promise for cancer research and is frequently utilized in such studies.
NSC 295642 (CAS 77111-29-6) References
- Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. | Beshir, AB., et al. 2008. Bioorg Med Chem Lett. 18: 498-504. PMID: 18240381
- Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? | Bagnyukova, TV., et al. 2010. Cancer Biol Ther. 10: 839-53. PMID: 20935499
- Cell-active dual specificity phosphatase inhibitors identified by high-content screening. | Vogt, A., et al. 2005. Drug Discov Today. Suppl: 3-12. PMID: 23570161
- Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3. | Donaubauer, EM., et al. 2016. J Biol Chem. 291: 19701-12. PMID: 27422819
- Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. | Escuin-Ordinas, H., et al. 2016. Nat Commun. 7: 12348. PMID: 27476449
- Superior long-term synaptic memory induced by combining dual pharmacological activation of PKA and ERK with an enhanced training protocol. | Liu, RY., et al. 2017. Learn Mem. 24: 289-297. PMID: 28620076
- Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. | Bhore, N., et al. 2017. Int J Mol Sci. 18: PMID: 28902166
- Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement. | Wei, X., et al. 2023. Bioorg Chem. 130: 106278. PMID: 36413930
- Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways. | Liu, RY., et al. 2022. Learn Mem. 29: 435-446. PMID: 36446603
- Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable? | Shillingford, SR. and Bennett, AM. 2023. Annu Rev Pharmacol Toxicol. 63: 617-636. PMID: 36662585
Inhibitor of:
HisRS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 295642, 5 mg | sc-253204 | 5 mg | $310.00 | |||
NSC 295642, 10 mg | sc-253204A | 10 mg | $540.00 | |||
NSC 295642, 50 mg | sc-253204B | 50 mg | $2200.00 |