Molecular structure of NSC 109555 ditosylate, CAS Number: 66748-43-4
NSC 109555 ditosylate (CAS 66748-43-4)
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Alternate Names:
4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate
Application:
NSC 109555 ditosylate is a reversible ATP-competitive Chk2 inhibitor
CAS Number:
66748-43-4
Molecular Weight:
752.86
Molecular Formula:
C19H24N10O•2C7H8O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC 109555 ditosylate is an ATP-competitive reversible Chk2 (checkpoint kinase 2) inhibitor that displays no effect on a range of other kinases, including Chk1. NSC 109555 ditosylate inhibits H1 phosphorylation as well as attenuates mitochondrial ATP synthesis.
NSC 109555 ditosylate (CAS 66748-43-4) References
Byczkowski et al (1981) Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 30 2851. Byczkowski et al (1982) Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 42 3592. Jobson et al (2007) Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 72 876.Inhibitor of:
Chk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 109555 ditosylate, 10 mg | sc-204137 | 10 mg | $185.00 | |||
| US: Only available in the US | ||||||
NSC 109555 ditosylate, 50 mg | sc-204137A | 50 mg | $781.00 | |||
| US: Only available in the US | ||||||