Molecular structure of NS3694, CAS Number: 426834-38-0
NS3694 (CAS 426834-38-0)
See product citations (2)
Alternate Names:
4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid; Apoptosis Inhibitor II
Application:
NS3694 is a suppressor of the formation of apoptosome Apaf-1
CAS Number:
426834-38-0
Purity:
≥95%
Molecular Weight:
358.70
Molecular Formula:
C15H10ClF3N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NS3694 also known as Apoptosis Inhibitor II is a cell-permeable diarylurea compound that suppresses the formation of the apoptosome Apaf-1. Studies suggest that the main component to signal the activation of apoptosis is the release of mitochondrial proapoptotic proteins into the cytosol which leads to the activation of caspases which form the apoptosome. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. However, NS3694 does not exhibit any effect on apoptosome-independent caspase activation and enzymatic activity of caspases.
NS3694 (CAS 426834-38-0) References
- Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. | Lademann, U., et al. 2003. Mol Cell Biol. 23: 7829-37. PMID: 14560026
- Apoptosis is required during early stages of tail regeneration in Xenopus laevis. | Tseng, AS., et al. 2007. Dev Biol. 301: 62-9. PMID: 17150209
- Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors. | Mondragón, L., et al. 2008. J Med Chem. 51: 521-9. PMID: 18197610
- Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. | Zhao, CQ., et al. 2010. Age (Dordr). 32: 161-77. PMID: 19960285
- Enhanced survival of transplanted human adipose-derived stem cells by co-delivery with liposomal apoptosome inhibitor in fibrin gel matrix. | Shim, G., et al. 2013. Eur J Pharm Biopharm. 85: 673-81. PMID: 23747743
- Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. | Gauron, C., et al. 2013. Sci Rep. 3: 2084. PMID: 23803955
- Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy. | Gaur, S., et al. 2015. Oncotarget. 6: 29161-77. PMID: 26313360
- Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. | Jo, MJ., et al. 2015. Eur J Pharmacol. 769: 257-65. PMID: 26607468
- A model for investigating developmental eye repair in Xenopus laevis. | Kha, CX., et al. 2018. Exp Eye Res. 169: 38-47. PMID: 29357285
- Developmental dependence for functional eye regrowth in Xenopus laevis. | Kha, CX. and Tseng, KA. 2018. Neural Regen Res. 13: 1735-1737. PMID: 30136686
- Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. | Brock, CK., et al. 2019. Nat Commun. 10: 1044. PMID: 30837472
- A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation. | Tashakor, A., et al. 2019. FEBS Open Bio. 9: 1194-1203. PMID: 31033240
- Inhibition of glycogen catabolism induces intrinsic apoptosis and augments multikinase inhibitors in hepatocellular carcinoma cells. | Barot, S., et al. 2019. Exp Cell Res. 381: 288-300. PMID: 31128107
- Wheat Bran for Colon Cancer Prevention: The Synergy between Phytochemical Alkylresorcinol C21 and Intestinal Microbial Metabolite Butyrate. | Zhao, Y., et al. 2019. J Agric Food Chem. 67: 12761-12769. PMID: 31675233
- The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation. | Aztekin, C., et al. 2020. Development. 147: PMID: 31988186
Inhibitor of:
Apoptosis.Activator of:
caspase-9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NS3694, 10 mg | sc-203823 | 10 mg | $122.00 | |||
NS3694, 50 mg | sc-203823A | 50 mg | $587.00 |