Molecular structure of NS 1643, CAS Number: 448895-37-2
NS 1643 (CAS 448895-37-2)
See product citations (3)
Alternate Names:
N,N′-Bis[2-hydroxy-5-(trifluoromethyl)phenyl] urea
Application:
NS 1643 is an antiarrhythmic activator of hERG K+ channels
CAS Number:
448895-37-2
Molecular Weight:
380.25
Molecular Formula:
C15H10F6N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NS 1643 is a HERG(hERG K+ channel) activator, such as KCNH6. Displays different molecular mechanisms of action at hERG1 and hERG2 channels. Exhibits antiarrhythmic activity in vitro.
NS 1643 (CAS 448895-37-2) References
- Erg K+ channels modulate contractile activity in the bovine epididymal duct. | Mewe, M., et al. 2008. Am J Physiol Regul Integr Comp Physiol. 294: R895-904. PMID: 18184764
- Electrophysiologic characterization of a novel hERG channel activator. | Su, Z., et al. 2009. Biochem Pharmacol. 77: 1383-90. PMID: 19426677
- A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). | Lu, HR., et al. 2013. J Pharmacol Toxicol Methods. 68: 250-259. PMID: 23337247
- hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism. | Perez-Neut, M., et al. 2016. Oncotarget. 7: 58893-58902. PMID: 25945833
- Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma. | Perez-Neut, M., et al. 2016. Oncotarget. 7: 21991-2004. PMID: 26942884
- Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression. | Huo, J., et al. 2016. Clin Exp Pharmacol Physiol. 43: 851-61. PMID: 27199074
- Human Engineered Heart Tissue: Analysis of Contractile Force. | Mannhardt, I., et al. 2016. Stem Cell Reports. 7: 29-42. PMID: 27211213
- CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information. | Nozaki, Y., et al. 2017. Regul Toxicol Pharmacol. 88: 238-251. PMID: 28634147
- NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2. | Huo, J., et al. 2017. Clin Exp Pharmacol Physiol. 44: 1125-1133. PMID: 28741726
- ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. | Xiao, K., et al. 2018. J Physiol. 596: 4729-4752. PMID: 30016551
- Utility of the JT Peak Interval and the JT Area in Determining the Proarrhythmic Potential of QT-Shortening Agents. | Qiu, B., et al. 2019. J Cardiovasc Pharmacol Ther. 24: 160-171. PMID: 30092655
- Electrophysiological Profile Remodeling via Selective Suppression of Voltage-Gated Currents by CLN1/PPT1 Overexpression in Human Neuronal-Like Cells. | Demontis, GC., et al. 2020. Front Cell Neurosci. 14: 569598. PMID: 33390903
Inhibitor of:
CLC-7, CLIC3, EAG, and neurexin II.Activator of:
HERG, KCNE3, KCNH3, KCNH4, KCNH5, KCNH6, KCNQ1, KCTD16, KV1.5, KV2.2, LRRC26, PLEKHJ1, SK1, and TMEM205.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NS 1643, 10 mg | sc-204135 | 10 mg | $123.00 | |||
NS 1643, 50 mg | sc-204135A | 50 mg | $473.00 |