Nrf2 Antibody (437C2a): sc-81342
- Nrf2 Antibody (437C2a) is a mouse monoclonal IgG1 κ, cited in 30 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Nrf2 of human origin
- recommended for detection of Nrf2 of human origin by WB and IP
- See Nrf2 (A-10): sc-365949 for Nrf2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nrf2 Antibody (437C2a). This work is in progress.
Nrf2 Antibody (437C2a) is a mouse monoclonal IgG1 antibody raised against a recombinant protein corresponding to an internal region of Nrf2 of human origin and is recommended for use in western blotting (WB) and immunoprecipitation (IP) applications. Nrf2, a key regulator of the cellular response to oxidative stress, plays a crucial role in maintaining cellular homeostasis by activating the expression of antioxidant and detoxifying enzymes. Nrf2 protein is primarily located in the cytoplasm under normal conditions, where Keap1 maintains regulatory control. Upon exposure to oxidative stress or xenobiotics, Nrf2 is released from Keap1 and translocates to the nucleus, where binding to antioxidant response elements (ARE) in the promoter regions of target genes leads to transcriptional activation. This translocation is vital for the cellular defense mechanism against oxidative damage, as Nrf2 enhances the expression of genes involved in detoxification and antioxidant responses, such as NQO1. The Nrf2 pathway is not only essential for protecting cells from oxidative stress but also plays a significant role in various physiological processes, including inflammation and metabolism, making Nrf2 a critical target for therapeutic interventions in diseases associated with oxidative stress and inflammation. Anti-Nrf2 antibody (437C2a) provides a valuable tool for studying the regulation, localization, and functional dynamics of Nrf2 in oxidative stress-related pathways and cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nrf2 Antibody (437C2a) | sc-81342 | 100 µg/ml | $339.00 |