NPY 5RA972 CAS: 439861-56-0
MF: C21H25N3O2
MW: 351.44
A potent and selective NPY5-R antagonist.

NPY 5RA972 (CAS 439861-56-0)

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Application: NPY 5RA972 is a potent and selective NPY5-R antagonist
CAS Number: 439861-56-0
Molecular Weight: 351.44
Molecular Formula: C21H25N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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NPY 5RA972 is a potent and selective NPY5-R (neuropeptide Y) antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for NPY5-R, NPY1-R, NPY2-R and NPY4-R respectively). This compound does not block NPY-induced feeding in vivo. NPY 5RA972 has also been shown to be a brain penetrant.


References

Block et al (2002) Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 45 3509. Turnbull et al (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51 2441. Morris et al (2007) Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 25 1136.

Physical State :
Solid
Solubility :
DMSO (100mM)
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9884833
SMILES :
CC1=C(C=CC2=C1C3=CC=CC=C3N2C(C)C)NC(=O)N4CCOCC4

Download SDS (MSDS)

Certificate of Analysis

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