Molecular structure of N′-Methylnicotinamide, CAS Number: 114-33-0
N′-Methylnicotinamide (CAS 114-33-0)
See product citations (3)
Alternate Names:
N-methylpyridine-3-carboxamide
Application:
N′-Methylnicotinamide is a metabolite of nicotinamide
CAS Number:
114-33-0
Purity:
≥98%
Molecular Weight:
136.15
Molecular Formula:
C7H8N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N′-Methylnicotinamide is a metabolite of nicotinamide, also known as vitamin B3. N′-methylnicotinamide is a water-soluble small molecule that has been extensively studied for its potential to regulate energy metabolism and protect cells against oxidative stress. Several scientific studies have examined its effects on cell proliferation, apoptosis, and gene expression in vitro. It can be synthesized from various sources, including formaldehyde and nicotinamide.
N′-Methylnicotinamide (CAS 114-33-0) References
- The metabolism of nicotinamide in human liver cirrhosis: a study on N-methylnicotinamide and 2-pyridone-5-carboxamide production. | Pumpo, R., et al. 2001. Am J Gastroenterol. 96: 1183-7. PMID: 11316167
- The excretion of N'-methylnicotinamide and N'-methyl-2-pyridone-5-carboxylamide in leprosy and the response to DDS therapy. | KINNEAR, AA. 1957. S Afr J Lab Clin Med. 3: 63-6. PMID: 13432951
- Effect of N'-methylnicotinamide on the renal accumulation and reabsorption of gentamicin in rats. | Jerauld, R. and Silverblatt, FJ. 1978. Antimicrob Agents Chemother. 13: 893-4. PMID: 149514
- N-methylnicotinamide inhibits arterial thrombosis in hypertensive rats. | Mogielnicki, A., et al. 2007. J Physiol Pharmacol. 58: 515-27. PMID: 17928647
- N-methylnicotinamide failed to induce endothelial prostacyclin release in perfused rat hindquarters. | Mogielnicki, A., et al. 2008. Pharmacol Rep. 60: 1025-9. PMID: 19212000
- N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. | Bi, HC., et al. 2014. Carcinogenesis. 35: 2264-72. PMID: 25115443
- Correlation between niacin equivalent intake and urinary excretion of its metabolites, N'-methylnicotinamide, N'-methyl-2-pyridone-5-carboxamide, and N'-methyl-4-pyridone-3-carboxamide, in humans consuming a self-selected food. | Shibata, K. and Matsuo, H. 1989. Am J Clin Nutr. 50: 114-9. PMID: 2526576
- N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. | Jiang, N., et al. 2016. Mol Nutr Food Res. 60: 1625-36. PMID: 26887666
- Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia. | Zabielska, MA., et al. 2018. Pharmacol Rep. 70: 378-384. PMID: 29477947
- Formation of the N'-methylnicotinamide adenine dinucleotide derivative of NAD in intact rat pituitary tumor GH3 and human promyelocytic leukemia HL-60 cells. | Johnson, GS. and Lucas, DL. 1986. Arch Biochem Biophys. 249: 148-53. PMID: 3017219
- Simultaneous determination of nicotinamide and N1 -methylnicotinamide in human serum by LC-MS/MS to associate their serum concentrations with obesity. | Chu, J., et al. 2022. Biomed Chromatogr. 36: e5261. PMID: 34716608
- Effect of probenecid and N'-methylnicotinamide on renal handling of cis-dichlorodiammineplatinum-II in rats. | Osman, NM. and Litterst, CL. 1983. Cancer Lett. 19: 107-11. PMID: 6221790
- N'-Methylnicotinamide in human urine. | Holmen, H., et al. 1981. Biomed Mass Spectrom. 8: 122-4. PMID: 6453630
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N′-Methylnicotinamide, 5 g | sc-295821 | 5 g | $94.00 | |||
N′-Methylnicotinamide, 25 g | sc-295821A | 25 g | $276.00 |