Molecular structure of NPC-15437 dihydrochloride, CAS Number: 136449-85-9
NPC-15437 dihydrochloride (CAS 136449-85-9)
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Alternate Names:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride
Application:
NPC-15437 dihydrochloride is a selective protein kinase C (PKC) inhibitor
CAS Number:
136449-85-9
Molecular Weight:
511.61
Molecular Formula:
C25H50N4O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NPC-15437 dihydrochloride is a selective inhibitor of PKC (protein kinase C).
NPC-15437 dihydrochloride (CAS 136449-85-9) References
- The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. | Mathis, C., et al. 1992. Eur J Pharmacol. 220: 107-10. PMID: 1425976
- Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats. | Aujla, H. and Beninger, RJ. 2003. Behav Brain Res. 147: 41-8. PMID: 14659568
- 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. | Sullivan, JP., et al. 1992. Mol Pharmacol. 41: 38-44. PMID: 1732721
- 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C. | Sullivan, JP., et al. 1991. Agents Actions. 34: 142-4. PMID: 1793019
- NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs. | Sullivan, JP., et al. 1991. FEBS Lett. 285: 120-3. PMID: 2065775
- A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior. | Plaza-Zabala, A., et al. 2013. Neuropsychopharmacology. 38: 1724-36. PMID: 23518606
- Spinal activation of protein kinase C elicits phrenic motor facilitation. | Devinney, MJ. and Mitchell, GS. 2018. Respir Physiol Neurobiol. 256: 36-42. PMID: 29081358
- Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats. | Walker, DL. and Gold, PE. 1994. Neurosci Lett. 176: 255-8. PMID: 7830959
- Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)- hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro. | Sha, EC., et al. 1996. Invest New Drugs. 13: 285-94. PMID: 8824346
- Heterogeneity of signal transduction mechanisms in human basophils and human skin mast cells. II. Effects of 7-O-methyl-UCN-01, NPC 15437 and bryostatin 1 and 2, four protein kinase C-modulatory agents, on mediator release. | Noll, T., et al. 1997. Biol Signals. 6: 1-10. PMID: 9098518
Inhibitor of:
PKC, Protease, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPC-15437 dihydrochloride, 1 mg | sc-202742 | 1 mg | $102.00 | |||
NPC-15437 dihydrochloride, 5 mg | sc-202742A | 5 mg | $315.00 |