Molecular structure of Norverapamil, Hydrochloride, CAS Number: 67812-42-4
Norverapamil, Hydrochloride (CAS 67812-42-4)
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Alternate Names:
α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)- benzene acetonitrile
Application:
Norverapamil, Hydrochloride is a calcium channel protein inhibitor
CAS Number:
67812-42-4
Purity:
≥99%
Molecular Weight:
477.04
Molecular Formula:
C26H36N2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Norverapamil hydrochloride is recognized as the primary metabolite of Verapamil, a calcium channel blocker. In the realm of analytical chemistry, Norverapamil hydrochloride plays a role as a reference standard in the quantitative determination of Verapamil and its metabolites in biological samples. By understanding the behavior of Norverapamil, researchers can gain insights into the metabolism of Verapamil, including the identification of metabolic pathways and the quantification of metabolite concentrations over time. Such investigations help in elucidating the enzymatic processes involved in the biotransformation of Verapamil.
Norverapamil, Hydrochloride (CAS 67812-42-4) References
- The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil. | Johnson, BM., et al. 2001. J Pharm Pharmacol. 53: 1611-9. PMID: 11804391
- Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry. | Dethy, JM., et al. 2003. Anal Chem. 75: 805-11. PMID: 12622370
- An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. | Johnson, BM., et al. 2002. AAPS PharmSci. 4: E40. PMID: 12646011
- Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism. | Mudra, DR. and Borchardt, RT. 2010. J Pharm Sci. 99: 982-98. PMID: 19746412
- Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats. | Hu, N., et al. 2011. Drug Metab Dispos. 39: 419-25. PMID: 21135265
- In-line capillary electrophoretic evaluation of the enantioselective metabolism of verapamil by cytochrome P3A4. | Asensi-Bernardi, L., et al. 2013. J Chromatogr A. 1298: 139-45. PMID: 23751364
- High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. | van Domburg, B., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1129: 121793. PMID: 31629310
- Comparative pharmacokinetics of verapamil and norverapamil in normal and ulcerative colitis rats after oral administration of low and high dose verapamil by UPLC-MS/MS. | Yao, H., et al. 2020. Xenobiotica. 50: 713-721. PMID: 31633443
- Short-chain fatty acids oppositely altered expressions and functions of intestinal cytochrome P4503A and P-glycoprotein and affected pharmacokinetics of verapamil following oral administration to rats. | Zhang, J., et al. 2020. J Pharm Pharmacol. 72: 448-460. PMID: 31863502
- Determination of Verapamil Hydrochloride and Norverapamil Hydrochloride in Rat Plasma by Capillary Electrophoresis With End-Column Electrochemiluminescence Detection and Their Pharmacokinetics Study. | Sun, S., et al. 2021. J Chromatogr Sci. 59: 289-296. PMID: 33333557
- Stereoselective determination of verapamil and norverapamil by capillary electrophoresis. | Dethy, JM., et al. 1994. J Chromatogr B Biomed Appl. 654: 121-7. PMID: 8004233
Inhibitor of:
Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Norverapamil, Hydrochloride, 5 mg | sc-212427 | 5 mg | $346.00 |