Molecular structure of Norgestrel, CAS Number: 6533-00-2
Norgestrel (CAS 6533-00-2)
Alternate Names:
Ovrette
Application:
Norgestrel is a synthetic progesterone analog
CAS Number:
6533-00-2
Molecular Weight:
312.45
Molecular Formula:
C21H28O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Norgestrel is a progestogen that functions as a progestin. It acts by binding to and activating the progesterone receptor, leading to the inhibition of ovulation. Norgestrel also alters the cervical mucus, making it more difficult for sperm to reach the uterus. Norgestrel affects the endometrium, making it less receptive to implantation. At the molecular level, Norgestrel modulates gene transcription, leading to changes in the reproductive system that prevent pregnancy. Its mechanism of action involves disrupting the normal hormonal feedback mechanisms involved in the menstrual cycle, ultimately preventing fertilization. Norgestrel′s function in experimental applications involves its role as a progestogen, influencing various aspects of the reproductive system to prevent conception.
Norgestrel (CAS 6533-00-2) References
- Impact of subdermal norgestrel on hepatic acyl-coenzyme A:cholesterol- acyltransferase (ACAT) activity: possible antiatherogenic effect. | Letterie, GS. 2000. Contraception. 61: 391-4. PMID: 10958883
- Bone density changes during two years treatment with tibolone or conjugated estrogens and norgestrel, compared with untreated controls in postmenopausal women. | Milner, M., et al. 2000. Menopause. 7: 327-33. PMID: 10993032
- All progestins are not created equal. | Stanczyk, FZ. 2003. Steroids. 68: 879-90. PMID: 14667980
- Enantiomeric separation of norgestrel by reversed phase high-performance liquid chromatography using eluents containing hydroxypropyl-beta-cyclodextrin in stereoselective skin permeation study. | Ye, J., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 843: 289-94. PMID: 16837251
- Norgestrel may be a potential therapy for retinal degenerations. | Doonan, F. and Cotter, TG. 2012. Expert Opin Investig Drugs. 21: 579-81. PMID: 22375616
- Mini-pill in lactating women. | Canto, TE., et al. 1989. Contraception. 39: 589-601. PMID: 2752751
- Effects of conjugated equine oestrogens with and without the addition of cyclical norgestrel on serum and urine electrolytes, and the biochemical indices of bone metabolism and liver function. | Fletcher, CD., et al. 1988. Maturitas. 9: 347-57. PMID: 2837620
- Automated stability-indicating high-performance liquid chromatographic assay for ethinyl estradiol and (levo)norgestrel tablets. | Reif, VD., et al. 1987. Pharm Res. 4: 54-8. PMID: 3150042
- Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study. | Zhao, X., et al. 2023. Sci Total Environ. 871: 162110. PMID: 36764532
- In vitro exposure to environmentally relevant concentrations of norgestrel affects sperm physiology and reproductive success of the Pacific oyster Crassostrea gigas. | Xu, S., et al. 2023. Mar Environ Res. 186: 105938. PMID: 36870161
- Plasma levels of ethinyl oestradiol and norgestrel during hormone replacement therapy. | Dennerstein, L., et al. 1980. Maturitas. 2: 147-54. PMID: 7207216
- Efficacy and safety of a monophasic and a triphasic oral contraceptive containing norgestimate. | Corson, SL. 1994. Am J Obstet Gynecol. 170: 1556-61. PMID: 8178906
- Desogestrel, norgestimate, and gestodene: the newer progestins. | Kaplan, B. 1995. Ann Pharmacother. 29: 736-42. PMID: 8520092
- Disappearance of (14,15-3H)d,1-norgestrel from plasma and its distribution in the reproductive tract of women. | Uniyal, JP., et al. 1976. Acta Endocrinol (Copenh). 82: 851-64. PMID: 947291
Inhibitor of:
Progesterone.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Norgestrel, 100 mg | sc-205415 | 100 mg | $39.00 | |||
Norgestrel, 500 mg | sc-205415A | 500 mg | $174.00 |