Date published: 2025-9-26

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Norfentanyl (CAS 1609-66-1)

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CAS Number:
1609-66-1
Purity:
99%
Molecular Weight:
232.3
Molecular Formula:
C14H20N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Norfentanyl is a metabolite of fentanyl, extensively studied in the field of analytical toxicology. Forensic scientists analyze this compound as a biomarker to assess fentanyl exposure, given its presence in biological samples following metabolism. The compound′s stability and detectability make it a target in the development of sophisticated analytical methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), aimed at improving the sensitivity and specificity of chemical monitoring assays. In environmental toxicology, norfentanyl is monitored to understand the environmental fate and persistence of synthetic opioids, which can have implications for water safety and wildlife exposure. Additionally, chemists are interested in the synthetic pathways that lead to norfentanyl, as it provides a model for studying the phase I metabolic processes involving N-dealkylation that occur in the liver.


Norfentanyl (CAS 1609-66-1) References

  1. Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection.  |  Koch, DE., et al. 2004. J Pharm Biomed Anal. 34: 577-84. PMID: 15127814
  2. Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC-MS/MS.  |  Huynh, NH., et al. 2005. J Pharm Biomed Anal. 37: 1095-100. PMID: 15862690
  3. LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems.  |  Coopman, V., et al. 2007. Forensic Sci Int. 169: 223-7. PMID: 16650707
  4. Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical period.  |  Tanaka, N., et al. 2014. Ther Drug Monit. 36: 345-52. PMID: 24365989
  5. Reply to 'Using postmortem blood and urine norfentanyl/fentanyl ratios in the investigation of fentanyl-related deaths'.  |  Spiller, HA., et al. 2016. Clin Toxicol (Phila). 54: 894. PMID: 27314533
  6. Using postmortem blood and urine norfentanyl/fentanyl ratios in the investigation of fentanyl-related deaths.  |  Ruan, X., et al. 2016. Clin Toxicol (Phila). 54: 893. PMID: 27314754
  7. Fentanyl-Norfentanyl Concentrations During Transdermal Patch Application: LC-MS-MS Urine Analysis.  |  Cummings, OT., et al. 2016. J Anal Toxicol. 40: 595-600. PMID: 27405369
  8. The distribution and redistribution of fentanyl & norfentanyl in post mortem samples.  |  Chatterton, CN. and Scott-Ham, M. 2018. Forensic Sci Int. 284: 146-152. PMID: 29408723
  9. Protracted renal clearance of fentanyl in persons with opioid use disorder.  |  Huhn, AS., et al. 2020. Drug Alcohol Depend. 214: 108147. PMID: 32650192
  10. Delayed Norfentanyl Clearance During Pregnancy.  |  Wanar, A., et al. 2020. Obstet Gynecol. 136: 905-907. PMID: 33030873
  11. Determination of Fentanyl, Alpha-Methylfentanyl, Beta-Hydroxyfentanyl and the Metabolite Norfentanyl in Rat Urine by LC-MS-MS.  |  Li, L., et al. 2022. J Anal Toxicol. 46: 421-431. PMID: 33647104
  12. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC-MS/MS.  |  Mahowald, G., et al. 2022. J Appl Lab Med. 7: 854-862. PMID: 35259249
  13. Determination of fentanyl and norfentanyl in cerumen in the setting of postmortem investigation.  |  Mastrogianni, O., et al. 2022. J Forensic Sci. 67: 2130-2137. PMID: 35642729

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Norfentanyl, 1 mg

sc-222077
1 mg
$69.00

Norfentanyl, 10 mg

sc-222077A
10 mg
$411.00