NOR-3 CAS: 163180-49-2
MF: C8H13N3O4
MW: 215.21
A cell-permeable NO donor.

NOR-3 (CAS 163180-49-2)

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Alternate Names: FK 409; (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
Application: NOR-3 is a cell-permeable NO donor
CAS Number: 163180-49-2
Purity: >98%
Molecular Weight: 215.21
Molecular Formula: C8H13N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

NOR-3 is a cell-permeable, non-thiol, nitric oxide (NO) donor that can spontaneously release NO in a rate controlled manner (half-life in PBS, pH 7.4 is 30 minutes at 37°C) generating biologically inactive by-products. NOR-3 spontaneously releases NO intra- and extracellularly and activates intracellular soluble guanylate cyclase, leading to an increase in cGMP level and subsequent vascular relaxation and inhibition of platelet aggregation. NORs release NO at a steady rate, although the mechanism of release is not yet known.


References

1. Yamada, H., et al., 1991. Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog. British journal of pharmacology. 103(3): 1713-8. PMID: 1681975
2. Shibata, S., et al., 1991. Characteristics of the vasorelaxing action of (3E)-4-ethyl-2-hydroximino-5-nitro-3-hexamide FK409, a new vasodilator isolated from microbial sources, in isolated rabbit arteries. Journal of cardiovascular pharmacology. 17(3): 508-18. PMID: 1711615
3. Hino, M., et al., 1989. FK409, a novel vasodilator isolated from the acid-treated fermentation broth of Streptomyces griseosporeus. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. The Journal of antibiotics. 42(11): 1578-83. PMID: 2584140
4. Kita, Y., et al., 1994. Antiplatelet activities of FK409, a new spontaneous NO releaser. British journal of pharmacology. 113(2): 385-8. PMID: 7834188
5. Kita, Y., et al., 1994. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. European journal of pharmacology. 257(1-2): 123-30. PMID: 8082692
6. Percival, M D., et al., 1999. Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid. Biochemistry. 38(41): 13574-83. PMID: 10521264

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
244.80° C (Predicted)
Boiling Point :
428.17° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6437875
MDL Number :
MFCD00270892
SMILES :
CCC(=CC(=NO)C(=O)N)C(C)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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