Molecular structure of NOR-1, CAS Number: 163032-70-0
NOR-1 (CAS 163032-70-0)
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Alternate Names:
(+/-)-(E)-Methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexeneamide
CAS Number:
163032-70-0
Molecular Weight:
231.21
Molecular Formula:
C8H13N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A novel non-thiol-based NO donor which releases NO under physiological conditions with a half-life of 1.7 minutes1. Inhibits cysteine proteases2.
NOR-1 (CAS 163032-70-0) References
- Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid. | Percival, MD., et al. 1999. Biochemistry. 38: 13574-83. PMID: 10521264
- Endothelin-1-induced vasoconstriction is inhibited during erection in rats. | Mills, TM., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 281: R476-83. PMID: 11448850
- Further investigations into the endothelium-dependent hyperpolarizing effects of bradykinin and substance P in porcine coronary artery. | Edwards, G., et al. 2001. Br J Pharmacol. 133: 1145-53. PMID: 11487526
- NOR-1: a nitric oxide releasing agent for calibrating low levels of nitric oxide by the chemiluminescence method. | Ueki, Y., et al. 2002. Blood Coagul Fibrinolysis. 13: 75-80. PMID: 11914648
- Inhibition of cysteine protease activity by NO-donors. | Ascenzi, P., et al. 2001. Curr Protein Pept Sci. 2: 137-53. PMID: 12370021
- ET-1- and NO-mediated signal transduction pathway in human brain capillary endothelial cells. | Chen, Y., et al. 2003. Am J Physiol Cell Physiol. 284: C243-9. PMID: 12529247
- Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways. | Song, JS., et al. 2007. Respir Res. 8: 28. PMID: 17391532
- Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon. | Hidaka, A., et al. 2010. J Pharmacol Sci. 112: 231-41. PMID: 20118618
- Na/Ca(2+) exchanger 1 transgenic mice display increased relaxation in the distal colon. | Nishiyama, K., et al. 2014. Pharmacology. 94: 230-8. PMID: 25427675
- Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. | Kita, Y., et al. 1994. Eur J Pharmacol. 257: 123-30. PMID: 8082692
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOR-1, 10 mg | sc-202736 | 10 mg | $291.00 |