Date published: 2026-4-4

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(+)-Nootkatone (CAS 4674-50-4)

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CAS Number:
4674-50-4
Purity:
≥98%
Molecular Weight:
218.33
Molecular Formula:
C15H22O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(+)-Nootkatone is a organic compound found in grapefruit, and it is responsible for the characteristic aroma of the fruit. It is a sesquiterpene and is classified as a ketone. (+)-Nootkatone has insecticidal properties and is used as a insect repellent. It is used in the fragrance industry due to its pleasant scent. (+)-Nootkatone has been studied for its potential as a flavoring agent beverages.


(+)-Nootkatone (CAS 4674-50-4) References

  1. RIFM fragrance ingredient safety assessment, nootkatone, CAS Registry Number 4674-50-4.  |  Api, AM., et al. 2020. Food Chem Toxicol. 141 Suppl 1: 111426. PMID: 32461160
  2. Nootkatone attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats.  |  Meeran, MFN., et al. 2021. Phytomedicine. 84: 153405. PMID: 33636578
  3. Nootkatone Is an Effective Repellent against Aedes aegypti and Aedes albopictus.  |  Clarkson, TC., et al. 2021. Insects. 12: PMID: 33925333
  4. Engineering Nootkatone Biosynthesis in Artemisia annua.  |  Gou, Y., et al. 2021. ACS Synth Biol. 10: 957-963. PMID: 33973783
  5. Advances on (+)-nootkatone microbial biosynthesis and its related enzymes.  |  Li, X., et al. 2021. J Ind Microbiol Biotechnol. 48: PMID: 34279658
  6. Nootkatone protects cartilage against degeneration in mice by inhibiting NF-κB signaling pathway.  |  Xu, Y., et al. 2021. Int Immunopharmacol. 100: 108119. PMID: 34492535
  7. Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests.  |  Yang, R., et al. 2021. J Agric Food Chem. 69: 15544-15553. PMID: 34919380
  8. Mode of action and toxicological effects of the sesquiterpenoid, nootkatone, in insects.  |  Norris, EJ., et al. 2022. Pestic Biochem Physiol. 183: 105085. PMID: 35430075
  9. Nootkatone alleviates rotenone-induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway.  |  Yao, Z., et al. 2022. Phytother Res. 36: 4183-4200. PMID: 35833337
  10. Separation and purification of nootkatone from fermentation broth of Yarrowia lipolytica with high-speed counter-current chromatography.  |  Li, X., et al. 2022. J Food Sci Technol. 59: 4487-4498. PMID: 36193467
  11. Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review.  |  Zhang, LL., et al. 2023. J Agric Food Chem. 71: 121-142. PMID: 36541855
  12. Nootkatone Supplementation Attenuates Carbon Tetrachloride Exposure-Induced Nephrotoxicity in Mice.  |  Dai, C., et al. 2023. Antioxidants (Basel). 12: PMID: 36829928

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(+)-Nootkatone, 1 g

sc-250579
1 g
$173.00