Molecular structure of Nolatrexed Dihydrochloride, CAS Number: 152946-68-4
Nolatrexed Dihydrochloride (CAS 152946-68-4)
Alternate Names:
2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq
Application:
Nolatrexed Dihydrochloride is an inhibitor of thymidylate synthase
CAS Number:
152946-68-4
Purity:
≥98%
Molecular Weight:
357.26
Molecular Formula:
C14H14Cl2N4OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antineoplastic. Antifolate thymidylate synthase inhibitor.
Nolatrexed Dihydrochloride (CAS 152946-68-4) References
- A Phase II trial of nolatrexed dihydrochloride in patients with advanced hepatocellular carcinoma. | Stuart, K., et al. 1999. Cancer. 86: 410-4. PMID: 10430248
- Nucleobase- and p-glycoprotein-mediated transport of AG337 in a Caco-2 cell culture model. | Hu, M. and Chen, J. 2004. Mol Pharm. 1: 194-200. PMID: 15981922
- Enhancement of thymidylate synthase inhibition. | Nord, LD. and Martin, DS. 1993. Curr Opin Oncol. 5: 1017-22. PMID: 8305534
- Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. | Webber, SE., et al. 1993. J Med Chem. 36: 733-46. PMID: 8459400
- AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. | Webber, S., et al. 1996. Cancer Chemother Pharmacol. 37: 509-17. PMID: 8612303
- Solid-state characterization of AG337 (Thymitaq), a novel antitumor drug. | Dash, AK. and Tyle, P. 1996. J Pharm Sci. 85: 1123-7. PMID: 8897283
- A glimpse of the future. new directions in the treatment of colorectal cancer. | Van Cutsem, E. 1996. Eur J Cancer. 32A Suppl 5: S23-7. PMID: 8958039
- Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents. | Bavetsias, V. and Jackman, AL. 1998. Curr Med Chem. 5: 265-88. PMID: 9668195
- Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion. | Rafi, I., et al. 1995. Clin Cancer Res. 1: 1275-84. PMID: 9815922
Inhibitor of:
DHFRL1, GART, TMSL3, and TS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nolatrexed Dihydrochloride, 10 mg | sc-208103 | 10 mg | $260.00 |