NOC-5 (CAS 146724-82-5)
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NOC-5 is recognized for its pivotal role as a nitric oxide (NO) donor, where it forms a stable NO-amine complex capable of autonomously releasing two equivalents of nitric oxide in solution under physiological conditions, negating the need for any cofactors. This feature makes it an invaluable tool in biochemical research, particularly in studies aimed at understanding the myriad roles of nitric oxide in cellular signaling and physiological processes. The kinetics of NOC-5 is characterized by a half-life of 93 minutes in phosphate-buffered saline (PBS) at a neutral pH of 7.4 and a temperature of 22°C, indicating a moderate rate of NO release. Notably, the stability of NOC-5 enhances in alkaline conditions, with optimal stability observed at pH levels equal to or greater than 10. This property is of significant interest in experimental setups requiring prolonged or controlled release of nitric oxide, thereby offering researchers a versatile tool for investigating the effects of NO in various biochemical pathways and cellular responses.
NOC-5 (CAS 146724-82-5) References
- NONOates regulate KCl cotransporter-1 and -3 mRNA expression in vascular smooth muscle cells. | Di Fulvio, M., et al. 2003. Am J Physiol Heart Circ Physiol. 284: H1686-92. PMID: 12521940
- Ketamine and thiopental sodium: individual and combined neuroprotective effects on cortical cultures exposed to NMDA or nitric oxide. | Shibuta, S., et al. 2006. Br J Anaesth. 97: 517-24. PMID: 16928698
- Articular chondrocyte aging and endothelin-1. | Khatib, AM., et al. 2007. Cytokine. 37: 6-13. PMID: 17382552
- Proinflammatory cytokines suppress the expression level of protease-activated receptor-2 through the induction of iNOS in rat colon. | Horie, A., et al. 2009. J Vet Med Sci. 71: 1609-15. PMID: 20046028
- Nitric oxide blocks cellular heme insertion into a broad range of heme proteins. | Waheed, SM., et al. 2010. Free Radic Biol Med. 48: 1548-58. PMID: 20211245
- Spectrophotometric activity microassay for pure and recombinant cytochrome P450-type nitric oxide reductase. | Garny, S., et al. 2014. Anal Biochem. 447: 23-9. PMID: 24239572
- Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. | Starikova, EG., et al. 2014. Cell Biol Int. 38: 799-802. PMID: 24677341
- Characterisation and comparison of temporal release profiles of nitric oxide generating donors. | Bradley, SA. and Steinert, JR. 2015. J Neurosci Methods. 245: 116-24. PMID: 25749567
- Dispersal of human and plant pathogens biofilms via nitric oxide donors at 4 °C. | Marvasi, M., et al. 2016. AMB Express. 6: 49. PMID: 27457245
- Complexes of nitric oxide with nucleophiles as agents for the controlled biological release of nitric oxide: hemodynamic effect in the rabbit. | Diodati, JG., et al. 1993. J Cardiovasc Pharmacol. 22: 287-92. PMID: 7692171
- NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages. | Shimaoka, M., et al. 1995. Biochem Biophys Res Commun. 209: 519-26. PMID: 7733920
- Inhibition of Cu2+-induced LDL oxidation by nitric oxide: a study using donors with different half-time of NO release. | Seccia, M., et al. 1996. Biochem Biophys Res Commun. 220: 306-9. PMID: 8645301
- 'NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. | Keefer, LK., et al. 1996. Methods Enzymol. 268: 281-93. PMID: 8782594
- Nitric oxide-induced cytotoxicity attenuation by thiopentone sodium but not pentobarbitone sodium in primary brain cultures. | Shibuta, S., et al. 1998. Br J Pharmacol. 124: 804-10. PMID: 9690874
- Cleavage product from the NO donor NOC-5 and inner ear hair cell damage. | Takayama, M., et al. 1998. Acta Otolaryngol Suppl. 538: 12-8. PMID: 9879394
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOC-5, 1 mg | sc-202248A | 1 mg | $59.00 | |||
NOC-5, 5 mg | sc-202248B | 5 mg | $156.00 | |||
NOC-5, 10 mg | sc-202248 | 10 mg | $216.00 | |||
NOC-5, 25 mg | sc-202248C | 25 mg | $410.00 |