Molecular structure of NOC-12, CAS Number: 146724-89-2
NOC-12 (CAS 146724-89-2)
See product citations (3)
Alternate Names:
3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene
Application:
NOC-12 is a diazeniumdiolate NO donor
CAS Number:
146724-89-2
Purity:
≥97%
Molecular Weight:
176.22
Molecular Formula:
C6H16N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NOC-12 is a diazeniumdiolate (NONOate) small molecule NO donor with a long NO release half-life of 327 minutes at 22degC. NOC-12 presents an NO donor with a half-life of release intermediate between NOC-9 (sc-202250, half-life 2.7 min) and NOC-18 (sc-202247, half-life 20 hr). NO release from NOC-12 and NOC-18 demonstrated inhibition of pulmonary artery smooth muscle cell proliferation with associated cGMP increase. NOC-12 mediated NO-release was shown to increase cGMP levels and protect cells against H2O2-induced damage and reperfusion.
NOC-12 (CAS 146724-89-2) References
- Lack of interaction between nitric oxide and the redox modulatory site of the NMDA receptor. | Aizenman, E. and Potthoff, WK. 1999. Br J Pharmacol. 126: 296-300. PMID: 10051148
- Role of nitric oxide in regulating neonatal porcine pulmonary artery smooth muscle cell proliferation. | Ambalavanan, N., et al. 1999. Biol Neonate. 76: 291-300. PMID: 10516396
- Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia. | Tao, YX. and Johns, RA. 2000. Eur J Pharmacol. 392: 141-5. PMID: 10762667
- The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism. | Takuma, K., et al. 2002. Jpn J Pharmacol. 89: 64-71. PMID: 12083744
- Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel. | Sun, J., et al. 2003. J Biol Chem. 278: 8184-9. PMID: 12509428
- Retinal neuronal death induced by intraocular administration of a nitric oxide donor and its rescue by neurotrophic factors in rats. | Takahata, K., et al. 2003. Invest Ophthalmol Vis Sci. 44: 1760-6. PMID: 12657619
- Evidence that nitric oxide regulates the acute effects of ethanol on rat N-methyl-D-aspartate receptors in vitro. | Costa, ET., et al. 2003. Neurosci Lett. 343: 41-4. PMID: 12749993
- Nitric oxide enhances osteoclastogenesis possibly by mediating cell fusion. | Nilforoushan, D., et al. 2009. Nitric Oxide. 21: 27-36. PMID: 19389479
- Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes. | Calamia, V., et al. 2011. BMC Musculoskelet Disord. 12: 237. PMID: 22004293
- Role of new agents affecting NO/cGMP pathway on ovalbumin-sensitized guinea pig trachea. | Parlak, A., et al. 2012. Exp Lung Res. 38: 420-6. PMID: 23030645
- Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism. | de Andrés, MC., et al. 2013. Arthritis Res Ther. 15: R115. PMID: 24025112
- Signaling Mechanisms in the Nitric Oxide Donor- and Amphetamine-Induced Dopamine Release in Mesencephalic Primary Cultured Neurons. | Salum, C., et al. 2016. Neurotox Res. 29: 92-104. PMID: 26391887
- The nitric oxide-cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus. | Okuyama, E., et al. 2021. Physiol Rep. 9: e14938. PMID: 34288526
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOC-12, 10 mg | sc-202246 | 10 mg | $260.00 |