Molecular structure of NOB, CAS Number: 55894-52-5
NOB (CAS 55894-52-5)
See product citations (1)
Alternate Names:
4-Nitro-3-(octanoyloxy)benzoic acid
CAS Number:
55894-52-5
Purity:
≥98%
Molecular Weight:
309.30
Molecular Formula:
C15H19NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
NOB (CAS 55894-52-5), also known as 4-Nitro-3-(octanoyloxy)benzoic acid, serves as a chromogenic substrate specifically designed for phospholipases like PLA2 that are derived from snake venoms and human serum. Its absorbance can be measured at 425 nm. It demonstrates solubility in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Extensive research has focused on examining the potential biochemical and physiological effects of NOB, revealing inhibitory properties against the growth of certain bacteria and fungi, as well as its ability to hinder the activity of the enzyme cyclooxygenase. Moreover, it exhibits anti-inflammatory and antioxidant properties. Notably, this compound has also been investigated for its potential to lower cholesterol levels and function as an anti-cancer agent.
NOB (CAS 55894-52-5) References
- A simple assay for a human serum phospholipase A2 that is associated with high-density lipoproteins. | Petrovic, N., et al. 2001. J Lipid Res. 42: 1706-13. PMID: 11590228
- Enzymatic and structural characterization of new PLA2 isoform isolated from white venom of Crotalus durissus ruruima. | Diz Filho, EB., et al. 2009. Toxicon. 53: 104-14. PMID: 19013478
- Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor. | Fonseca, FV., et al. 2010. Toxicon. 55: 1527-30. PMID: 20223257
- Quercetin as an inhibitor of snake venom secretory phospholipase A2. | Cotrim, CA., et al. 2011. Chem Biol Interact. 189: 9-16. PMID: 21056032
- Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom. | Ximenes, RM., et al. 2012. BMC Complement Altern Med. 12: 139. PMID: 22925825
- Acute toxicity of vipoxin and its components: is the acidic component an 'inhibitor' of PLA2 toxicity? | Atanasov, VN., et al. 2012. Interdiscip Toxicol. 5: 169-72. PMID: 23554559
- Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae). | Estrada-Gomez, S., et al. 2015. Toxins (Basel). 7: 2872-87. PMID: 26264023
- Venom from Opisthacanthus elatus scorpion of Colombia, could be more hemolytic and less neurotoxic than thought. | Estrada-Gómez, S., et al. 2016. Acta Trop. 153: 70-8. PMID: 26477848
- Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A₂ from Colombian Bothrops asper Venom. | Posada Arias, S., et al. 2017. Toxins (Basel). 9: PMID: 29072602
- Insights into the candidacidal mechanism of Ctn[15-34] - a carboxyl-terminal, crotalicidin-derived peptide related to cathelicidins. | Cavalcante, CSP., et al. 2018. J Med Microbiol. 67: 129-138. PMID: 29214974
- Prospective study of a Bothrops jararacussu venom batch (Bj2015) - phospholipase A2 activity, immunogenicity, neurotoxicity, and myotoxicity parameters. | Oliveira, ICF., et al. 2019. Nat Prod Res. 33: 2417-2421. PMID: 29495880
- Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2. | Bryan-Quirós, W., et al. 2019. Toxicon. 157: 1-7. PMID: 30447275
- Distinctive Distribution of Secretory Phospholipases A₂ in the Venoms of Afro-Asian Cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus). | Tan, CH., et al. 2019. Toxins (Basel). 11: PMID: 30769779
- Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants. | Bustillo, S., et al. 2019. Toxicon. 168: 113-121. PMID: 31326508
- Structural, enzymatic and pharmacological profiles of AplTX-II - A basic sPLA2 (D49) isolated from the Agkistrodon piscivorus leucostoma snake venom. | Resende, LM., et al. 2021. Int J Biol Macromol. 175: 572-585. PMID: 33529631
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOB, 50 mg | sc-471095 | 50 mg | $163.00 | |||
NOB, 250 mg | sc-471095A | 250 mg | $469.00 |