Molecular structure of NO-Indomethacin, CAS Number: 301838-28-8
NO-Indomethacin (CAS 301838-28-8)
Alternate Names:
NCX 2121
Application:
NO-Indomethacin is a Cox-1 and Cox-2 inhibitor and NO donor
CAS Number:
301838-28-8
Molecular Weight:
620.07
Molecular Formula:
C28H30ClN3O9S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
NO-Indomethacin is a hybrid molecule of indomethacin (sc-200503) and a nitric oxide (NO) donor. This design combines the anti-inflammatory and Cox -1 and -2 inhibitory properties of indomethacin with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to indomethacin alone. NO-Indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 μM, compared to >1,000 μM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.
NO-Indomethacin (CAS 301838-28-8) References
1. Wallace, John L., et al., 1997. Gastrointestinal-sparing anti-inflammatory drugs: the development of nitric oxide-releasing NSAIDs. Drug development research. 42(3-4):144-149.2. Kashfi, Khosrow, et al., 2002. Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-dependent effect. The journal of pharmacology and experimental therapeutics. 303(3): 1273.1282.
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NO-Indomethacin, 1 mg | sc-205414 | 1 mg | $25.00 | |||
NO-Indomethacin, 5 mg | sc-205414A | 5 mg | $108.00 | |||
NO-Indomethacin, 10 mg | sc-205414B | 10 mg | $192.00 | |||
NO-Indomethacin, 50 mg | sc-205414C | 50 mg | $849.00 |