NNC 63-0532 CAS: 250685-44-0
MF: C27H29N3O3
MW: 443.54
A potent non-peptide agonist for the NOP receptor.

NNC 63-0532 (CAS 250685-44-0)

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Alternate Names: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Application: NNC 63-0532 is a potent non-peptide agonist for the NOP receptor
CAS Number: 250685-44-0
Molecular Weight: 443.54
Molecular Formula: C27H29N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).

NNC 63-0532 is a potent non-peptide agonist for the KOR-3 (NOP receptor) (EC50 = 305 nM, Ki = 7.3 nM); about a 12-fold increase in selectivity over other receptors.


References

1. Thomsen, C. and Hohlweg, R. 2000. Br. J. Pharmacol. 131: 903-908.

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mM), and DMSO (50 mM).
Storage :
Store at room temperature
Melting Point :
259.06° C (Predicted)
Boiling Point :
~645.8° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
NOP receptor: EC5050 = 305 nM
Ki Data :
NOP receptor: Ki= 7.3 nM
pK Values :
pKb: 8.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD04113779
SMILES :
COC(=O)CN1CN(C2(C1=O)CCN(CC2)CC3=CC=CC4=CC=CC=C43)C5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

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