Molecular structure of NNC 63-0532, CAS Number: 250685-44-0
NNC 63-0532 (CAS 250685-44-0)
Alternate Names:
8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Application:
NNC 63-0532 is a potent non-peptide agonist for the NOP receptor
CAS Number:
250685-44-0
Molecular Weight:
443.54
Molecular Formula:
C27H29N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NNC 63-0532 is involved in the regulation of certain cellular processes, particularly those related to metabolism and energy production. NNC 63-0532 interacts with specific enzymes and receptors within the cell, influencing their activity and ultimately impacting the function of the cell. NNC 63-0532 modulate certain signaling pathways, which can have far-reaching effects on cellular function and communication. It it is clear that NNC 63-0532 is an important player in the complicated network of biochemical processes that govern cellular function.
NNC 63-0532 (CAS 250685-44-0) References
- (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. | Thomsen, C. and Hohlweg, R. 2000. Br J Pharmacol. 131: 903-8. PMID: 11053209
- Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors. | Zaveri, N., et al. 2001. Eur J Pharmacol. 428: 29-36. PMID: 11779034
- The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands. | Jong, L., et al. 2004. Bioorg Med Chem Lett. 14: 181-5. PMID: 14684324
- Molecular modelling studies on the ORL1-receptor and ORL1-agonists. | Bröer, BM., et al. 2003. J Comput Aided Mol Des. 17: 739-54. PMID: 15072434
- Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity. | Guerrini, R., et al. 2004. J Pept Res. 63: 477-84. PMID: 15175020
- Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist. | Trapella, C., et al. 2006. Bioorg Med Chem. 14: 692-704. PMID: 16202610
- Agonist-regulated endocytosis and desensitization of the human nociceptin receptor. | Spampinato, S. and Baiula, M. 2006. Neuroreport. 17: 173-7. PMID: 16407766
- Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5. | Camarda, V., et al. 2009. Naunyn Schmiedebergs Arch Pharmacol. 379: 599-607. PMID: 19183962
- NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. | Gear, RW., et al. 2014. Neuroscience. 257: 139-48. PMID: 24188792
- Involvement of neurotransmitters in the action of the nociceptin/orphanin FQ peptide-receptor system on passive avoidance learning in rats. | Palotai, M., et al. 2014. Neurochem Res. 39: 1477-83. PMID: 24893797
- Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor. | Chang, SD., et al. 2015. Mol Pharmacol. 88: 502-11. PMID: 26134494
- A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. | Rorick-Kehn, LM., et al. 2016. Alcohol Clin Exp Res. 40: 945-54. PMID: 27084498
- Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus. | da Silva, JA., et al. 2017. Psychopharmacology (Berl). 234: 3009-3025. PMID: 28856406
- Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. | Mann, A., et al. 2019. Sci Signal. 12: PMID: 30914485
- Roles of K+ and cation channels in ORL-1 receptor-mediated depression of neuronal excitability and epileptic activities in the medial entorhinal cortex. | Li, H., et al. 2019. Neuropharmacology. 151: 144-158. PMID: 30998945
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KOR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NNC 63-0532, 10 mg | sc-203648 | 10 mg | $306.00 | |||
| US: Only available in the US | ||||||
NNC 63-0532, 50 mg | sc-203648A | 50 mg | $1326.00 | |||
| US: Only available in the US | ||||||