Molecular structure of NNC 26-9100, CAS Number: 199522-35-5
NNC 26-9100 (CAS 199522-35-5)
Alternate Names:
1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Application:
NNC 26-9100 is a somatostatin SSTR4 (sst4 receptor) agonist
CAS Number:
199522-35-5
Purity:
≥99%
Molecular Weight:
556.35
Molecular Formula:
C22H25N6Cl2SBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NNC 26-9100 is an agonist of the somatostatin subtype-4 (sst4) receptor, which inhibits forskolin-induced cAMP accumulation. It is known that somatostatin is a cyclic tetradecapeptide that is a potent inhibitor of growth hormone (GH). NNC 26-9100 is composed of four main fragments which include a heteroaromatic moiety comprised of pyridine, an aromatic group, basic imidazole group, and a thiourea scaffold. Research suggest that NNC 26-9100 is essential in the discovery of other thiourea compounds that function as agonists towards the sst4 receptor.
NNC 26-9100 (CAS 199522-35-5) References
- Evidence that somatostatin sst2 receptors mediate striatal dopamine release. | Hathway, GJ., et al. 1999. Br J Pharmacol. 128: 1346-52. PMID: 10578151
- Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells. | Smith, PA., et al. 2001. J Physiol. 532: 127-42. PMID: 11283230
- Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice. | Sandoval, KE., et al. 2011. Eur J Pharmacol. 654: 53-9. PMID: 21185826
- Somatostatin receptor subtype-4 agonist NNC 26-9100 decreases extracellular and intracellular Aβ₁₋₄₂ trimers. | Sandoval, KE., et al. 2012. Eur J Pharmacol. 683: 116-24. PMID: 22449380
- Inhibitory effect of somatostatin receptor subtype-4 agonist NNC 26-9100 on micturition reflex in rats. | Honda, M., et al. 2012. Urology. 80: 1391.e9-13. PMID: 22951005
- Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. | Sandoval, KE., et al. 2013. Brain Res. 1520: 145-56. PMID: 23669069
- International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. | Günther, T., et al. 2018. Pharmacol Rev. 70: 763-835. PMID: 30232095
- Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice. | Sandoval, K., et al. 2019. Neurochem Res. 44: 2670-2680. PMID: 31630317
- Novel Drug-Like Somatostatin Receptor 4 Agonists are Potential Analgesics for Neuropathic Pain. | Kántás, B., et al. 2019. Int J Mol Sci. 20: PMID: 31835716
- Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease. | Kim, N. and Lee, HJ. 2020. Biomed Res Int. 2020: 2010728. PMID: 33224974
- In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists. | Kántás, B., et al. 2020. Front Pharmacol. 11: 601887. PMID: 33815096
- NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells. | Schober, J., et al. 2021. PLoS One. 16: e0254242. PMID: 34237100
- Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity. | Matiadis, D., et al. 2021. Biomedicines. 9: PMID: 34440159
Activator of:
SSTR4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NNC 26-9100, 10 mg | sc-361276 | 10 mg | $255.00 | |||
| US: Only available in the US | ||||||