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NMDAε1 Antibody (D-8) - Western Blotting - Image 286044
NMDAε1 (D-8): sc-390094. 大鼠脑 (A) 和小鼠脑 (B) 组织提取物中 NMDAε1 表达的 Western 印迹分析.
NMDAε1 Antibody (D-8) - Western Blotting - Image 286044
NMDAε1 (D-8): sc-390094. 大鼠脑 (A) 和小鼠脑 (B) 组织提取物中 NMDAε1 表达的 Western 印迹分析.
NMDAε1 (D-8): sc-390094. 大鼠脑 (A) 和小鼠脑 (B) 组织提取物中 NMDAε1 表达的 Western 印迹分析.

NMDAε1 抗体 (D-8): sc-390094

5.0(2)
寫評論提問

说明书
  • NMDAε1抗体(D-8)是小鼠单克隆IgG1 κ, 在7篇文献中引用，规格为200 µg/ml
  • 特定于human起源的NMDAε1的N-terminal胞外结构域内氨基酸31-69之间的表位图谱
  • 推荐用于 mouse, rat 和 human 来源的NMDAε1 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP是NMDAε1 Antibody (D-8) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与NMDAε1 Antibody (D-8) 搭配使用（请参阅下面的订购信息）。

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関連項目

附加NMDA抗体，包括NMDA ε 1, NMDA ε 2, NMDA ε 4和NMDA ζ 1

谷氨酸受体介导大脑中大多数兴奋性神经传递，并在神经可塑性、神经发育和神经退行性疾病中发挥重要作用。离子型谷氨酸受体分为NMDA受体和海藻酸/AMPA受体，两者都含有谷氨酸门控的阳离子特异性离子通道。海藻酸/AMPA受体与NMDA受体在许多突触中共定位，并由七个结构相关的亚基组成，称为GluR-1至-7。海藻酸/AMPA受体主要负责谷氨酸的快速兴奋性神经传递，而NMDA受体则表现出Ca2+离子的慢动力学和高Ca2+离子通透性。NMDA受体由五个亚基组成：ε 1、2、3、4和一个ζ亚基。ζ亚基在整个脑干中表达，而四个ε亚基显示有限分布。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NMDAε1 抗体 (D-8) 参考文献:

  1. 在静息状态下阻断 NMDA 受体可引发快速的行为抗抑郁反应。  |  Autry, AE., et al. 2011. Nature. 475: 91-5. PMID: 21677641
  2. NMDA 受体通道的结构、功能和药理学。  |  Vyklicky, V., et al. 2014. Physiol Res. 63: S191-203. PMID: 24564659
  3. NMDA 受体与精神分裂症：从病理生理学到治疗。  |  Balu, DT. 2016. Adv Pharmacol. 76: 351-82. PMID: 27288082
  4. 非常规 NMDA 受体信号。  |  Dore, K., et al. 2017. J Neurosci. 37: 10800-10807. PMID: 29118208
  5. 与 NMDA 受体抗体相关的脑炎。  |  Guasp, M. and Dalmau, J. 2018. Med Clin (Barc). 151: 71-79. PMID: 29183618
  6. 精神分裂症中 NMDA 受体功能低下的起源。  |  Nakazawa, K. and Sapkota, K. 2020. Pharmacol Ther. 205: 107426. PMID: 31629007
  7. 离子通量无关的 NMDA 受体信号传导。  |  Park, DK., et al. 2022. Neuropharmacology. 210: 109019. PMID: 35278420
  8. NMDA 受体的调节机制。  |  Mony, L. and Paoletti, P. 2023. Curr Opin Neurobiol. 83: 102815. PMID: 37988826
  9. NMDA 受体纳米域的跨突触分子环境。  |  Anderson, MC., et al. 2023. bioRxiv.. PMID: 38187545
  10. 氯胺酮通过突触诱捕缓解 NMDA 受体功能减退。  |  Villéga, F., et al. 2024. Neuron. 112: 3311-3328.e9. PMID: 39047728

订购信息

产品名称产品编号规格价格数量收藏夹

NMDAε1 抗体 (D-8)

sc-390094
200 µg/ml
$316.00

NMDAε1 (D-8): m-IgG Fc BP-HRP 套装

sc-540756
200 µg Ab; 10 µg BP
$354.00

NMDAε1 (D-8) 中和勝肽

sc-390094 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-390094 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24

Are you sure lane A is rat tissue and lane B is mouse tissue? Seems mouse Grin2a should be a little bit bigger than rat Grin2A (see your SC-1468 grin2a antibody C17)

Asked by: roy x
Thank you for your inquiry. These lanes were not side by side in the physical gel, and when the image was cropped and set unfortunately the alignment was off slightly. The bands actually run at visually the same weight, and the image will be reuploaded to reflect this. The predicted weight for both mouse and rat NMDAe1 is 177 kDa, both are glycosylated and we would expect them to migrate at the same weight. We do not have Western Blot data with the goat polyclonal NMDAe1 antibody sc-1468 from a rat tissue sample.
Answered by: Technical Service
Date published: 2016-12-15
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Rated 5 out of 5 by from NMDAε1 (GluN2A) Western blot applicationSingle band detected in mouse crude synaptosomal fraction at the expected molecular weight of 170 kDa. Antibody dilution 1:500.
Date published: 2023-04-13
Rated 5 out of 5 by from Good Western blot data of NMDA 1 expressionGood Western blot data of NMDA 1 expression in rat brain and mouse brain tissue extracts. -SCBT QC
Date published: 2014-05-18
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NMDAε1 抗体 (D-8) is rated 5.0 out of 5 by 2.
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