NKp44 Antibody (8F12): sc-59342

NKp44 Antibody (8F12) is a mouse monoclonal IgG3 antibody that detects NKp44 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NKp44 antibody (8F12) is available as a non-conjugated format, specifically designed to facilitate research into the role of natural killer (NK) cells in immune responses. NKp44 is a critical natural cytotoxicity receptor expressed on interleukin-2-activated human NK cells, playing a significant role in enhancing the cytotoxic activity of these cells against tumor and virally infected targets. NKp44′s structure includes one immunoglobulin-like extracellular domain, a transmembrane segment, and a cytoplasmic domain, which are essential for signaling and interaction with ligands. NKp44 interacts with a cellular ligand known as NKp44L, which is expressed during HIV-1 infection and has been linked to the progression of CD4+ T cell depletion and increased viral load. This interaction highlights NKp44′s potential as a therapeutic target in the development of vaccines for HIV-1, making NKp44 a valuable focus for ongoing immunological research. Prolactin up-regulates and cortisol down-regulates NKp44 surface expression at the transcriptional level, further emphasizing NKp44′s importance in immune modulation.

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NKp44 Antibody (8F12) References:

1. The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.  |  Cantoni, C., et al. 2003. Structure. 11: 725-34. PMID: 12791260
2. The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44).  |  De Maria, A., et al. 2003. Eur J Immunol. 33: 2410-8. PMID: 12938217
3. NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence.  |  Campbell, KS., et al. 2004. J Immunol. 172: 899-906. PMID: 14707061
4. Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30).  |  Mavoungou, E., et al. 2005. Clin Exp Immunol. 139: 287-96. PMID: 15654827
5. Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44.  |  Stet, RJ., et al. 2005. Immunogenetics. 57: 77-89. PMID: 15702329
6. Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44.  |  Fuchs, A., et al. 2005. Blood. 106: 2076-82. PMID: 15941912
7. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand.  |  Vieillard, V., et al. 2005. Proc Natl Acad Sci U S A. 102: 10981-6. PMID: 16046540
8. Expression of natural cytotoxicity receptors NKp30, NKp44, and NKp46 mRNAs and proteins by human hematopoietic and non-hematopoietic cells.  |  Srivastava, BI. and Srivastava, MD. 2006. Leuk Res. 30: 37-46. PMID: 16061284
9. Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D.  |  Forte, P., et al. 2005. J Immunol. 175: 5463-70. PMID: 16210654

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NKp44 Antibody (8F12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NKp44 Antibody (8F12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NKp44 Antibody (8F12) Specifications

Alternate Product Name: NKp44

Product Clone Name: 8F12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 19-130

Epitope Target: NKp44

Epitope Species: human

Product Reactivity/Detection: NKp44

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₃ in 500 µl of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NKp44 Antibody (8F12): N/A