NKG2-C Antibody (L45): sc-80237

NKG2-C Antibody (L45) is a mouse monoclonal IgG1 antibody that detects NKG2-C protein of human origin by flow cytometry (FCM). Anti-NKG2-C antibody (L45) is available as a non-conjugated format. NKG2-C, also known as killer cell lectin-like receptor subfamily C member 2 (KLRC2), plays a crucial role in immune response by regulating natural killer (NK) cell activity. NKG2-C protein is primarily located on NK cell surfaces, where NKG2-C forms a heterodimer with CD94, facilitating recognition of class I major histocompatibility complex (MHC) molecules. NKG2-C and CD94 interaction is essential for proper receptor transport to cell surfaces, where these receptors non-covalently associate with DAP12, enhancing expression and functionality. Upon binding to HLA-E ligand, CD94/NKG2-C complex activates NK cell cytolytic activity, which is vital for immune system′s ability to target and eliminate infected or malignant cells. NKG2-C′s ability to modulate NK cell responses underscores importance in immune surveillance and potential therapeutic applications in cancer and infectious diseases.

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NKG2-C Antibody (L45) References:

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2. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population.  |  Hikami, K., et al. 2003. Genes Immun. 4: 160-7. PMID: 12618865
3. Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses.  |  Ortega, C., et al. 2004. Immunol Cell Biol. 82: 587-95. PMID: 15550116
4. The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.  |  Gumá, M., et al. 2005. Eur J Immunol. 35: 2071-80. PMID: 15940674
5. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.  |  Houchins, JP., et al. 1997. J Immunol. 158: 3603-9. PMID: 9103421
6. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.  |  Braud, VM., et al. 1998. Nature. 391: 795-9. PMID: 9486650
7. Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.  |  Plougastel, B. and Trowsdale, J. 1998. Genomics. 49: 193-9. PMID: 9598306
8. Association of DAP12 with activating CD94/NKG2C NK cell receptors.  |  Lanier, LL., et al. 1998. Immunity. 8: 693-701. PMID: 9655483
9. The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.  |  Glienke, J., et al. 1998. Immunogenetics. 48: 163-73. PMID: 9683661