NK Cell Marker Antibody (ANK61): sc-59340

NK Cell Marker Antibody (ANK61) is a mouse monoclonal IgG1 antibody that detects NK Cell Marker protein of mouse and rat origin by immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). NK Cell Marker (ANK61) antibody is available as non-conjugated anti-NK Cell Marker antibody. Natural killer (NK) cells, which are large granular lymphocytes derived from bone marrow, play a crucial role in the innate immune system by identifying and eliminating infected or transformed cells. These cells are particularly important in early defense against viral infections, such as herpes, as NK cells can recognize and destroy cells compromised by pathogens. NK Cell Marker protein is essential for identification and characterization of immune cells, helping distinguish NK cells from other lymphocyte populations. Additionally, NK cells are equipped with specialized proteins, including perforin and granzymes, which facilitate cytotoxic function. Perforin forms pores in membranes of target cells, allowing granzymes to enter and induce apoptosis, thereby preventing infection spread. Understanding NK cell function and mechanisms is vital for developing immunotherapies and enhancing immune responses against various diseases.

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NK Cell Marker Antibody (ANK61) References:

1. On guard--activating NK cell receptors.  |  Lanier, LL. 2001. Nat Immunol. 2: 23-7. PMID: 11135574
2. The biology of human natural killer-cell subsets.  |  Cooper, MA., et al. 2001. Trends Immunol. 22: 633-40. PMID: 11698225
3. Biology and clinical relevance of human natural killer cells.  |  Robertson, MJ. and Ritz, J. 1990. Blood. 76: 2421-38. PMID: 2265240
4. Immunophenotypic demonstration of two natural killer surface markers, H25 and H366, on fresh human leukemic cells.  |  Körfer, A., et al. 1989. Acta Haematol. 82: 193-6. PMID: 2511721
5. Identification and Validation of a Novel Signature Based on NK Cell Marker Genes to Predict Prognosis and Immunotherapy Response in Lung Adenocarcinoma by Integrated Analysis of Single-Cell and Bulk RNA-Sequencing.  |  Song, P., et al. 2022. Front Immunol. 13: 850745. PMID: 35757748
6. NK cell marker gene-based model shows good predictive ability in prognosis and response to immunotherapies in hepatocellular carcinoma.  |  Li, J., et al. 2023. Sci Rep. 13: 7294. PMID: 37147523
7. Integrated analysis of single-cell and bulk RNA-sequencing reveals tumor heterogeneity and a signature based on NK cell marker genes for predicting prognosis in hepatocellular carcinoma.  |  Li, S., et al. 2023. Front Pharmacol. 14: 1200114. PMID: 37397471
8. Combining single-cell and bulk RNA sequencing, NK cell marker genes reveal a prognostic and immune status in pancreatic ductal adenocarcinoma.  |  Ouyang, Y., et al. 2024. Sci Rep. 14: 15037. PMID: 38951569
9. Two monoclonal antibodies identifying a subset of human peripheral mononuclear cells with natural killer cell activity.  |  Bai, Y., et al. 1983. Eur J Immunol. 13: 521-7. PMID: 6603362
10. Activation and function of natural killer cell responses during viral infections.  |  Biron, CA. 1997. Curr Opin Immunol. 9: 24-34. PMID: 9039782
11. The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity.  |  Brown, MG., et al. 1997. Immunol Rev. 155: 53-65. PMID: 9059882
12. Signal transduction during natural killer cell activation: inside the mind of a killer.  |  Leibson, PJ. 1997. Immunity. 6: 655-61. PMID: 9208838

The preferred IL-2 antibody is IL-2 Antibody (I2t-C7): sc-57285.