NK-92 Whole Cell Lysate: sc-364788

NK-92 whole cell lysate is derived from the NK-92 cell line, which originates from a patient with non-Hodgkin's lymphoma. This lysate is widely used in scientific research to study natural killer (NK) cell biology, including their mechanisms of cytotoxicity and immune regulation. NK-92 cells are known for their high cytotoxic activity and ability to kill tumor cells, making the lysate an invaluable tool for investigating NK cell signaling pathways and their role in immune responses. Researchers utilize NK-92 whole cell lysate to analyze the activation of key signaling molecules such as NF-κB, STAT3, and MAPK, which are crucial for regulating NK cell function and cytokine production. This lysate is also employed to study the expression and post-translational modifications of cytotoxic proteins like perforin and granzyme B, as well as surface receptors such as NKG2D and NKp46. Additionally, NK-92 whole cell lysate is used to evaluate the effects of various chemical modulators on NK cell activation and cytotoxicity, providing insights into the molecular mechanisms of immune regulation and tumor cell recognition. Recent research has leveraged this lysate for proteomic and transcriptomic analyses to identify novel proteins and signaling networks involved in NK cell function. NK-92 whole cell lysate thus remains a critical resource for advancing immunological research and understanding NK cell biology.