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Nizatidine (CAS 76963-41-2)

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Alternate Names:
N-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine
Application:
Nizatidine is an inhibitor of gastric acid secretion
CAS Number:
76963-41-2
Purity:
≥98%
Molecular Weight:
331.46
Molecular Formula:
C12H21N5O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nizatidine is a histamine H2 receptor antagonist which functions as a potent inhibitor of gastric acid secretion.


Nizatidine (CAS 76963-41-2) References

  1. Developmental pharmacokinetics and pharmacodynamics of nizatidine.  |  Abdel-Rahman, SM., et al. 2004. J Pediatr Gastroenterol Nutr. 38: 442-51. PMID: 15085026
  2. Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily.  |  Haag, S. and Holtmann, G. 2010. Clin Ther. 32: 678-90. PMID: 20435237
  3. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs.  |  Lin, TM., et al. 1986. J Pharmacol Exp Ther. 239: 406-10. PMID: 2877081
  4. Pharmacology and toxicology of nizatidine.  |  Morton, DM. 1987. Scand J Gastroenterol Suppl. 136: 1-8. PMID: 2892249
  5. A pharmacokinetic profile of nizatidine in man.  |  Callaghan, JT., et al. 1987. Scand J Gastroenterol Suppl. 136: 9-17. PMID: 2892261
  6. Nizatidine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease.  |  Price, AH. and Brogden, RN. 1988. Drugs. 36: 521-39. PMID: 2905640
  7. Regulatory Updates and Analytical Methodologies for Nitrosamine Impurities Detection in Sartans, Ranitidine, Nizatidine, and Metformin along with Sample Preparation Techniques.  |  Shaik, KM., et al. 2022. Crit Rev Anal Chem. 52: 53-71. PMID: 32691615
  8. Nizatidine interacts with ct-DNA causing genotoxicity and cytotoxicity: an assessment by in vitro, in vivo, and in silico studies.  |  Rahman, Y., et al. 2023. J Biomol Struct Dyn. 41: 538-549. PMID: 34856883
  9. Effects of ranitidine and nizatidine on the risk of gastrointestinal cancer.  |  Kang, H., et al. 2023. Front Oncol. 13: 1182174. PMID: 37576886
  10. Nizatidine anaphylaxis.  |  Mira-Perceval, JL., et al. 1996. J Allergy Clin Immunol. 97: 855-6. PMID: 8613644

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nizatidine, 5 g

sc-205771
5 g
$72.00

Nizatidine, 10 g

sc-205771A
10 g
$140.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Nizatidine, sc-205771, is in white to off-white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-05-19
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Rated 5 out of 5 by from Lin et alLin et al. (PubMed ID 2877081) found that the histamine H2 receptor antagonist, Nizatidine, potently inhibited gastric acid secretion. -SCBT Publication Review
Date published: 2015-02-14
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Nizatidine is rated 5.0 out of 5 by 1.
  • y_2026, m_4, d_20, h_8
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  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_205771, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
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