Nitrotyrosine Antibody (11C2): sc-101358
- Nitrotyrosine Antibody (11C2) is a mouse monoclonal IgG1, cited in 8 publications, provided at 500 µl supernatant
- raised against Nitrotyrosine
- recommended for detection of free and bound Nitrotyrosine by WB, IF, IHC(P) and ELISA; non cross-reactive with free or bound Tyrosine
- See Nitrotyrosine (39B6): sc-32757 for Nitrotyrosine antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nitrotyrosine Antibody (11C2). This work is in progress.
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Nitrotyrosine Antibody (11C2) is a mouse monoclonal IgG1 antibody that detects Nitrotyrosine in non-species restricted (NSR) applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Nitrotyrosine serves as a critical biomarker for inflammation and nitric oxide (NO) production, being formed when nitric oxide interacts with tyrosine residues in proteins, leading to the formation of peroxynitrite. This post-translational modification can indicate oxidative stress and cellular damage, which are pivotal in various pathological conditions. Elevated levels of nitrotyrosine have been associated with numerous inflammatory diseases, including septic shock, rheumatoid arthritis, celiac disease, atherosclerotic plaques, and chronic renal failure, making anti-Nitrotyrosine antibody (11C2) an essential tool for researchers investigating the role of nitric oxide in these conditions. Nitrotyrosine monoclonal antibody (11C2) enables scientists to gain insights into the mechanisms of NO-dependent damage and the broader implications of nitrotyrosine in disease progression and therapeutic responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nitrotyrosine Antibody (11C2) References:
- The determination of nitrotyrosine residues in proteins. | Gow, AJ., et al. 1998. Methods Mol Biol. 100: 291-9. PMID: 10907015
- Determination of nitrotyrosine by HPLC-ECD and its application. | Ishida, N., et al. 2002. J Vet Med Sci. 64: 401-4. PMID: 12069071
- Role of hyperglycemia in nitrotyrosine postprandial generation. | Ceriello, A., et al. 2002. Diabetes Care. 25: 1439-43. PMID: 12145247
- Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. | Shishehbor, MH., et al. 2003. JAMA. 289: 1675-80. PMID: 12672736
- Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. | Mani, AR., et al. 2003. Biochem J. 374: 521-7. PMID: 12797864
- A novel competitive ELISA for both free and protein-bound nitrotyrosine. | Qu, LN., et al. 2003. Hybrid Hybridomics. 22: 401-6. PMID: 14683602
- Plasma nitrotyrosine in reversible myocardial ischaemia. | Elfatih, A., et al. 2005. J Clin Pathol. 58: 95-6. PMID: 15623494
- Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells. | Teng, RJ., et al. 2016. Am J Physiol Cell Physiol. 310: C80-8. PMID: 26491046
- Monocyte chemotactic protein-1 and nitrotyrosine in irritable bowel syndrome. | Chira, A., et al. 2020. Exp Ther Med. 20: 24-30. PMID: 32508988
- Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation. | Yee, YH., et al. 2021. Redox Biol. 41: 101834. PMID: 33838472
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nitrotyrosine Antibody (11C2) | sc-101358 | 500 µl supernatant | $322.00 |