Nitrofurantoin-13C3 (CAS 67-20-9 (unlabeled))

Nitrofurantoin-13C3 is a labeled analog of nitrofurantoin, where three carbon atoms have been isotopically labeled with carbon-13 (13C), replacing the more common carbon-12 isotope. This isotopic modification is pivotal in enhancing the analytical detection and measurement of nitrofurantoin, particularly in complex chemical or biological matrices. The incorporation of 13C isotopes does not alter the chemical structure or reactivity of nitrofurantoin significantly, but it increases the molecular mass slightly, which can be precisely detected using mass spectrometry techniques. This makes Nitrofurantoin-13C3 an excellent internal standard in quantitative mass spectrometry, allowing for more accurate and sensitive analysis by providing a reference peak that can be distinguished from the natural abundance background. Researchers employ Nitrofurantoin-13C3 in studies focused on the environmental fate and biotransformation of nitrofurantoin, understanding how it behaves under various environmental conditions, how it degrades, and its persistence in different ecosystems. Additionally, this labeled compound is used in metabolic studies to trace and quantify metabolic pathways and to study the kinetics of nitrofurantoin absorption, distribution, and excretion in biological systems, providing insights into the compound′s behavior in various experimental settings without the influence of confounding variables.