Molecular structure of Nitrocefin, CAS Number: 41906-86-9
Nitrocefin (CAS 41906-86-9)
Alternate Names:
Nitrocefin is known as Nitrocephin.
Application:
Nitrocefin is a chromogenic cephalosporin substrate, commonly used to detect β-lactamases in bacteria.
CAS Number:
41906-86-9
Molecular Weight:
516.50
Molecular Formula:
C21H16N4O8S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nitrocefin is a chromogenic cephalosporin substrate, used to detect β-lactamases in bacteria. This trait of Nitrocefin is highly desirable, as the generation of β-lactamases leads to resistance to several antibiotics including penicillins and cephalosporins. Nitrocefin indicates the presence of β-lactamase activity by the appearance of a red color. The red color produced by Nitrocefin is proportional in intensity to the original concentration of Nitrocefin.
Nitrocefin (CAS 41906-86-9) References
- A practical synthesis of nitrocefin. | Lee, M., et al. 2005. J Org Chem. 70: 367-9. PMID: 15624952
- Modified nitrocefin-EDTA method to differentially quantify the induced L1 and L2 beta-lactamases in Stenotrophomonas maltophilia. | Hu, RM., et al. 2008. Lett Appl Microbiol. 47: 457-61. PMID: 19146537
- Overcoming resistance to β-lactam antibiotics. | Worthington, RJ. and Melander, C. 2013. J Org Chem. 78: 4207-13. PMID: 23530949
- Kinetic characterization of hydrolysis of nitrocefin, cefoxitin, and meropenem by β-lactamase from Mycobacterium tuberculosis. | Chow, C., et al. 2013. Biochemistry. 52: 4097-104. PMID: 23672214
- Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. | Ghavami, A., et al. 2015. Anal Biochem. 486: 75-7. PMID: 26142222
- A nitrocefin-based amperometric assay for the rapid quantification of extended-spectrum β-lactamase-producing Escherichia coli in wastewaters. | Chantemesse, B., et al. 2017. Water Res. 109: 375-381. PMID: 27951476
- A nitrocefin disc supplemented with ertapenem for rapid screening of carbapenemase-producing Enterobacteriaceae. | Teethaisong, Y., et al. 2018. Diagn Microbiol Infect Dis. 91: 85-88. PMID: 29422274
- Development of a rapid phenotypic test on a microfluidic device for carbapenemase detection using the chromogenic compound nitrocefin. | Allen, C., et al. 2020. Diagn Microbiol Infect Dis. 96: 114926. PMID: 32044188
- Antimicrobial Susceptibility Testing for Staphylococcus lugdunensis. | Teh, JSK., et al. 2022. J Clin Microbiol. 60: e0320220. PMID: 34705537
- Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. | Ahmadvand, P., et al. 2022. Int J Mol Sci. 23: PMID: 35563620
- Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. | Xie, L., et al. 2023. Cell Mol Life Sci. 80: 110. PMID: 37000222
- Antimicrobial effect of pimozide by targeting ROS-mediated killing in Staphylococcus aureus. | Kumar, S., et al. 2023. Biotechnol Appl Biochem.. PMID: 37000616
- Detection of beta-lactamase activity with nitrocefin of multiple strains of various microbial genera. | Uri, JV. 1985. Acta Microbiol Hung. 32: 133-45. PMID: 3933272
- Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. | O'Callaghan, CH., et al. 1972. Antimicrob Agents Chemother. 1: 283-8. PMID: 4208895
- Simple screening method for beta-lactamase-positive and -negative ampicillin-resistant Haemophilus influenzae isolates. | Parr, TR., et al. 1984. J Clin Microbiol. 20: 131-2. PMID: 6378964
- In vitro evaluation of pyridine-2-azo-p-dimethylaniline cephalosporin, a new diagnostic chromogenic reagent, and comparison with nitrocefin, cephacetrile, and other beta-lactam compounds. | Jones, RN., et al. 1982. J Clin Microbiol. 15: 677-83. PMID: 6978350
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nitrocefin, 1 mg | sc-478489C | 1 mg | $153.00 | |||
Nitrocefin, 5 mg | sc-478489D | 5 mg | $224.00 | |||
Nitrocefin, 10 mg | sc-478489 | 10 mg | $347.00 | |||
Nitrocefin, 25 mg | sc-478489A | 25 mg | $663.00 | |||
Nitrocefin, 50 mg | sc-478489B | 50 mg | $959.00 |