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Nitrilotriacetic acid disodium salt (CAS 15467-20-6)

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Alternate Names:
N,N-Bis(carboxymethyl)glycine; NTA; Triglycollamic acid
Application:
Nitrilotriacetic acid disodium salt is an excellent chelating agent
CAS Number:
15467-20-6
Purity:
≥99%
Molecular Weight:
235.10
Molecular Formula:
C6H7NO62Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nitrilotriacetic acid disodium salt, referred to as NTA, is used as a chelator of Ca2+, Cu2+, and Fe3+ ions that are found in hard water samples. Nitrilotriacetic acid disodium salt is also available as the free acid form, Nitrilotriacetic acid (sc-215578). Nitrilotriacetic acid disodium salt is similar to EDTA (sc-203932), but is more easily biodegradable.


Nitrilotriacetic acid disodium salt (CAS 15467-20-6) References

  1. 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules.  |  Okada, K., et al. 1999. J Biol Chem. 274: 23787-93. PMID: 10446139
  2. The effect of ferric-nitrilotriacetic acid on the profile of polyunsaturated fatty acids in the kidney and liver of rats.  |  Deiana, M., et al. 2001. Toxicol Lett. 123: 125-33. PMID: 11641040
  3. Kinetically controlled separation of cadmium(II) from zinc(II) with dithizone in the presence of nitrilotriacetic acid.  |  Itabashi, H., et al. 2001. Anal Sci. 17: 1301-4. PMID: 11759513
  4. Non-transferrin bound iron measurement is influenced by chelator concentration.  |  Kolb, AM., et al. 2009. Anal Biochem. 385: 13-9. PMID: 19026979
  5. Degradation of model olive mill contaminants of OMW catalysed by zero-valent iron enhanced with a chelant.  |  Sanchez, I., et al. 2012. J Hazard Mater. 199-200: 328-35. PMID: 22118846
  6. Induction of mesothelioma by intraperitoneal injections of ferric saccharate in male Wistar rats.  |  Okada, S., et al. 1989. Br J Cancer. 60: 708-11. PMID: 2803947
  7. High-performance liquid chromatographic, stability indicating assay for disodium EDTA in ophthalmic preparations.  |  Bauer, J., et al. 1986. J Chromatogr. 369: 422-5. PMID: 3100572
  8. Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis.  |  Cheng, Z., et al. 2022. Cancer Sci. 113: 65-78. PMID: 34699654
  9. BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance.  |  Kong, Y., et al. 2022. Redox Biol. 54: 102356. PMID: 35667247
  10. Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate.  |  Li, JL., et al. 1987. Cancer Res. 47: 1867-9. PMID: 3815378
  11. Acute renal failure and glucosuria induced by ferric nitrilotriacetate in rats.  |  Hamazaki, S., et al. 1985. Toxicol Appl Pharmacol. 77: 267-74. PMID: 3975899
  12. An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum.  |  Zhang, D., et al. 1995. Biochem Mol Biol Int. 35: 635-41. PMID: 7773198
  13. The effects of various chelating agents on the teratogenicity of lead nitrate in rats.  |  McClain, RM. and Siekierka, JJ. 1975. Toxicol Appl Pharmacol. 31: 434-42. PMID: 806992
  14. Oxidative stress response in iron-induced acute nephrotoxicity: enhanced expression of heat shock protein 90.  |  Fukuda, A., et al. 1996. Biochem Biophys Res Commun. 219: 76-81. PMID: 8619831

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nitrilotriacetic acid disodium salt, 50 g

sc-253192
50 g
$60.00

Nitrilotriacetic acid disodium salt, 100 g

sc-253192A
100 g
$123.00