Molecular structure of Nisoxetine hydrochloride, CAS Number: 57754-86-6
Nisoxetine hydrochloride (CAS 57754-86-6)
See product citations (3)
Alternate Names:
(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride; LY-94,939
Application:
Nisoxetine hydrochloride is a selective and potent inhibitor of norepinephrine transporter
CAS Number:
57754-86-6
Molecular Weight:
307.82
Molecular Formula:
C17H21NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nisoxetine hydrochloride is a selective and potent inhibitor of norepinephrine transporter with little or no affinity for a range of other neurotransmitter receptors. Nisoxetine hydrochloride is an inhibitor of SLC6A2. Nisoxetine has found a significant role for studying the norepinephrine (noradrenaline) system in the brain. Nisoxetine hydrochloride serves as a reference compound in the development and testing of new NRIs and other compounds targeting the norepinephrine system.
Nisoxetine hydrochloride (CAS 57754-86-6) References
- Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics. | Shang, Y. and Dluzen, DE. 2001. Neuroscience. 104: 957-64. PMID: 11457583
- Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors. | Fuller, RW., et al. 1975. Psychopharmacol Commun. 1: 455-64. PMID: 1228825
- Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS. | Di Benedetto, M., et al. 2004. Brain Res Mol Brain Res. 127: 115-20. PMID: 15306127
- Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat. | Chen, YW., et al. 2012. Eur J Pharmacol. 675: 22-5. PMID: 22166377
- Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats. | Leung, YM., et al. 2014. Fundam Clin Pharmacol. 28: 88-94. PMID: 22889000
- High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. | Bello, NT., et al. 2013. J Obes. 2013: 457047. PMID: 23431425
- Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. | Leung, YM., et al. 2013. Pharmacol Rep. 65: 350-7. PMID: 23744419
- Binge-like eating attenuates nisoxetine feeding suppression, stress activation, and brain norepinephrine activity. | Bello, NT., et al. 2014. PLoS One. 9: e93610. PMID: 24695494
- X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. | Penmatsa, A., et al. 2015. Nat Struct Mol Biol. 22: 506-508. PMID: 25961798
- Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. | Bermingham, DP., et al. 2016. Neurochem Int. 98: 122-8. PMID: 26850478
- Nisoxetine and amphetamine share discriminative stimulus properties in mice. | Snoddy, AM. and Tessel, RE. 1983. Pharmacol Biochem Behav. 19: 205-10. PMID: 6605539
- Nisoxetine prevents the 6-hydroxydopamine induced decrease in post-decapitation convulsions. | Bymaster, FB., et al. 1977. Life Sci. 20: 275-80. PMID: 839960
- Neuronal uptake inhibitors, nisoxetine and fluoxetine on rat vascular contractions. | Cohen, ML. and Wiley, KS. 1977. Eur J Pharmacol. 44: 219-29. PMID: 891602
- Effects of nisoxetine, a selective noradrenaline transporter blocker, on sleep in rats. | Python, A., et al. 1997. Pharmacol Biochem Behav. 58: 369-72. PMID: 9300594
Inhibitor of:
DGS8, and SLC6A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nisoxetine hydrochloride, 10 mg | sc-203646 | 10 mg | $133.00 | |||
| US: Only available in the US | ||||||
Nisoxetine hydrochloride, 50 mg | sc-203646A | 50 mg | $459.00 | |||
| US: Only available in the US | ||||||