Date published: 2026-4-1

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Nintedanib esylate (CAS 656247-18-6)

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Alternate Names:
Nintedanib, Ethanesulfonate Salt
Application:
Nintedanib esylate is the ethanesulfonate salt form of BIBF1120
CAS Number:
656247-18-6
Purity:
≥99%
Molecular Weight:
649.76
Molecular Formula:
C31H33N5O4•C2H6O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nintedanib Esylate is often utilized in research focused on fibrotic processes and the mechanisms involved in fibrosis. It is particularly of interest in studies related to its inhibitory action on multiple tyrosine kinases, which play a role in the signaling pathways that lead to fibrotic diseases. Researchers also investigate Nintedanib Esylate in relation to angiogenesis and the proliferation of vascular endothelial cells. The compound′s mechanism involves blocking the receptors for platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF), which are key molecules in these pathological processes. Additionally, Nintedanib Esylate is studied in the context of tissue remodeling, with a focus on understanding how inhibiting these signaling pathways can impact the extracellular matrix and cellular proliferation.


Nintedanib esylate (CAS 656247-18-6) References

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  2. Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1.  |  Lin, B., et al. 2018. Gene. 654: 77-86. PMID: 29454091
  3. Treatment of idiopathic pulmonary fibrosis with Nintedanib: an update.  |  Wongkarnjana, A., et al. 2019. Expert Rev Respir Med. 13: 1139-1146. PMID: 31564185
  4. Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma.  |  Shukla, SK., et al. 2020. Bioanalysis. 12: 159-174. PMID: 32052636
  5. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel.  |  Fourniols, T., et al. 2020. Int J Pharm. 584: 119337. PMID: 32371002
  6. Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship.  |  Epstein-Shochet, G., et al. 2020. Pulm Pharmacol Ther. 63: 101933. PMID: 32750409
  7. Inhaled nintedanib is well-tolerated and delivers key pharmacokinetic parameters required to treat bleomycin-induced pulmonary fibrosis.  |  Surber, MW., et al. 2020. Pulm Pharmacol Ther. 63: 101938. PMID: 32841676
  8. Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA.  |  Liang, GB., et al. 2021. Eur J Med Chem. 210: 112951. PMID: 33109400
  9. Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol.  |  Kok, LY., et al. 2022. Eur J Pharm Sci. 168: 106058. PMID: 34763088
  10. A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosis.  |  Cummins, KA., et al. 2021. APL Bioeng. 5: 046102. PMID: 34805716
  11. Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies.  |  Kala, SG. and Chinni, S. 2022. Drug Deliv Transl Res. 12: 2856-2864. PMID: 35322372
  12. Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity.  |  Zaky, MF., et al. 2022. Pharmaceutics. 15: PMID: 36678709
  13. Availability of Safe and Effective Therapeutic Options to Pregnant and Lactating Individuals Following the US FDA Pregnancy and Lactation Labeling Rule.  |  Patel, A., et al. 2023. J Pediatr.. PMID: 36806753
  14. A Sojourn on Liposomal Delivery System: Recent Advances and Future Prospects.  |  Kaur, S. and Singh, D. 2023. Assay Drug Dev Technol. 21: 48-64. PMID: 36856471

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nintedanib esylate, 25 mg

sc-396761
25 mg
$87.00

Nintedanib esylate, 50 mg

sc-396761A
50 mg
$114.00

Nintedanib esylate, 100 mg

sc-396761B
100 mg
$146.00

Nintedanib esylate, 500 mg

sc-396761C
500 mg
$312.00

Nintedanib esylate, 1 g

sc-396761D
1 g
$426.00