Molecular structure of Nimodipine, CAS Number: 66085-59-4
Nimodipine (CAS 66085-59-4)
See product citations (2)
Application:
Nimodipine is an L-type calcium channel protein inhibitor
CAS Number:
66085-59-4
Purity:
≥98%
Molecular Weight:
418.45
Molecular Formula:
C21H26N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nimodipine is a dihydropyridine calcium channel blocker that selectively interacts with voltage-gated calcium channels, particularly L-type calcium channels. Its primary mechanism of action revolves around the modulation of calcium influx through these channels, which are for various physiological processes, including muscle contraction, neurotransmitter release, and gene expression.
Nimodipine (CAS 66085-59-4) References
- Multiple types of high-threshold calcium channels in rabbit sensory neurons: high-affinity block of neuronal L-type by nimodipine. | McCarthy, RT. and TanPiengco, PE. 1992. J Neurosci. 12: 2225-34. PMID: 1318957
- Nimodipine and the recovery of memory. | Izquierdo, I. 1990. Trends Pharmacol Sci. 11: 309-10. PMID: 2203191
- Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. | Dolin, SJ., et al. 1988. Eur J Pharmacol. 152: 19-27. PMID: 2463174
- 1,4-Dihydropyridine activators and antagonists: structural and functional distinctions. | Triggle, DJ. and Rampe, D. 1989. Trends Pharmacol Sci. 10: 507-11. PMID: 2694544
- Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta-analysis. | Lin, RJ., et al. 2019. Laryngoscope. 129: 943-951. PMID: 30450691
- Enantioselective assay of nimodipine in human plasma using liquid chromatography-tandem mass spectrometry. | Isse, FA., et al. 2021. Biomed Chromatogr. 35: e4971. PMID: 32840898
- Nimodipine Attenuates Early Brain Injury by Protecting the Glymphatic System After Subarachnoid Hemorrhage in Mice. | Hou, C., et al. 2022. Neurochem Res. 47: 701-712. PMID: 34792752
- Nimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures. | Hohmann, U., et al. 2022. Int J Mol Sci. 23: PMID: 35328753
- Pial arterial vasodilation by intravenous nimodipine in cats. | Auer, LM. 1981. Arzneimittelforschung. 31: 1423-5. PMID: 7197947
- New uses for calcium channel blockers. Therapeutic implications. | Fisher, M. and Grotta, J. 1993. Drugs. 46: 961-75. PMID: 7510613
- Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. | Kappelle, AC., et al. 1994. Br J Pharmacol. 111: 887-93. PMID: 8019766
- Low-voltage activated calcium channels are differently affected by nimodipine. | Formenti, A., et al. 1993. Neuroreport. 5: 145-7. PMID: 8111001
- Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. | Batuecas, A., et al. 1998. Eur J Pharmacol. 350: 141-50. PMID: 9696401
Inhibitor of:
4930558K02Rik, 9130409J20Rik, APBA2BP, AZ2, C17orf57, C2CD4D, C3orf25, C6orf105, C6orf192, CA II, CA XI, CAB39L, CaBP2, CaBP4, Cacna2d1, Cacna2d2, Cacna2d4, Calcium Channel Protein, CALHM3, CaMKIγ, CAMTA1, CAPS-2, CatSperδ, Caytaxin, CCDC109B, Centrin, Centrin-3, Cerebellin 4, CLCA2_Clac2, CNTFRα, dendrin, densin-180, DJBP, DOC2A, EF-CBP2, EF-HC1, EG666504, Enkurin, IgLON (OBCAM), L-type Ca++ CP α1C, L-type Ca++ CP α1D, L-type Ca++ CP α1F, L-type Ca++ CP α1S, L-type Ca++ CP β1, L-type Ca++ CP β4, L-type Ca++ CP γ1, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ6, L-type Ca++ CP γ7, L-type Ca++ CP γ8, L-type calcium channel α1C, L-type calcium channel α1D, L-type calcium channel α1F, L-type calcium channel β1, L-type Calcium Channel γ, MCTP1, MDP-1, Mdr, N-type Ca++ CP α1B, NCKX5, neurexin I, neurocalcin, neurocalcin δ, neuroligin 3, NFATc3, NGL-1, nucleobindin, Olfr639, Olr1595, parvalbumin α, PCP-2, PMCA3, PSD2, PTPIP51, Raftlin, RIM-BP3A, ROG, S-100A3, S-100P, S-100Z, SCRN1, SHISA4, Stim1, TANC2, TMEM132E, TRAP-δ, Troponin C slow skeletal, VILIP-2, VILIP-3, and Vmn2r48.Activator of:
2610021K21Rik, ATP10A, BC060267, C14orf143, C17orf57, C2CD4D, Cacna2d3, calmodulin, calsyntenin-3, CaM II, CaM V, CaMKIδ, CBARA1, CHP2, CLRN2, copine 7, DREAM, DSCR 1, EF-CAB1, EF-CAB7, EF-CAB8, EF-HB, ELKS, GKAP, GlyR α2, Grid2ip, IQCJ, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP β2, L-type Ca++ CP γ4, L-type calcium channel β1, LOC285423, LOC85449, LRFN3, LRRTM2, NCKX1, NCKX6, Neurensin-2, Neuritin, Neurogranin, P/Q-type calcium channel α1A, PCDHB4, PP2B-Aβ, RasGRP4, S-100A5, SCG10, SV2C, Synaptotagmin VII, and T-type Ca++ CP α1I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nimodipine, 100 mg | sc-201464 | 100 mg | $61.00 | |||
Nimodipine, 1 g | sc-201464A | 1 g | $307.00 |