Molecular structure of Nimbolide
Nimbolide (CAS 25990-37-8)
Application:
Nimbolide is a terpenoid lactone derived that has been shown to cause TRAIL-induced apoptosis
CAS Number:
25990-37-8
Molecular Weight:
466.52
Molecular Formula:
C27H30O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 ŒM resulted in moderate to very str
Nimbolide (CAS 25990-37-8) References
- Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. | Moragoda, L., et al. 2001. Anticancer Res. 21: 873-8. PMID: 11396178
- Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. | Chang, KL., et al. 2004. Biochem Pharmacol. 67: 717-26. PMID: 14757171
- 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. | Parsels, LA., et al. 2004. Cancer Res. 64: 6588-94. PMID: 15374972
- Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica. | Khalid, SA., et al. 1989. J Nat Prod. 52: 922-6. PMID: 2607354
- Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism. | Jaiswara, PK., et al. 2021. Environ Toxicol. 36: 628-641. PMID: 33274819
- In vitro antibacterial activity of nimbolide against Helicobacter pylori. | Wylie, MR., et al. 2022. J Ethnopharmacol. 285: 114828. PMID: 34763046
- Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3. | Xia, D., et al. 2022. Toxicol Appl Pharmacol. 434: 115795. PMID: 34780724
- Nimbolide Targets Multiple Signalling Pathways to Reduce Neuroinflammation in BV-2 Microglia. | Katola, FO. and Olajide, OA. 2023. Mol Neurobiol.. PMID: 37314658
- Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer. | Li, P., et al. 2023. Sci Adv. 9: eadg7752. PMID: 37878693
- Cytotoxicity of nimbolide, epoxyazadiradione and other limonoids from neem insecticide. | Cohen, E., et al. 1996. Life Sci. 58: 1075-81. PMID: 8622560
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nimbolide, 5 mg | sc-397039 | 5 mg | $694.00 |