Nilotinib-d3 (CAS 1215678-43-5)

Nilotinib-d3, a deuterated derivative of nilotinib, has emerged as a valuable tool in scientific research, particularly in elucidating the pharmacokinetics and metabolic pathways of nilotinib. Deuteration involves replacing hydrogen atoms with deuterium, a stable isotope of hydrogen, which can alter the pharmacokinetic properties of the compound without significantly affecting its pharmacological activity. Nilotinib-d3 has been utilized in studies aiming to understand the absorption, distribution, metabolism, and excretion (ADME) profiles of nilotinib in various research settings. By incorporating deuterium into the structure of nilotinib, Nilotinib-d3 enables researchers to track the fate of the drug in biological systems more accurately using mass spectrometry-based techniques. Furthermore, Nilotinib-d3 serves as a valuable internal standard in analytical assays for quantifying nilotinib concentrations in biological samples, facilitating pharmacokinetic studies and bioanalytical method development. Research employing Nilotinib-d3 has contributed to a deeper understanding of nilotinib′s pharmacokinetic properties and its potential implications for optimizing dosing regimens. Overall, Nilotinib-d3 represents a crucial tool in pharmaceutical research, offering insights into drug metabolism and pharmacokinetics that can inform drug development and personalized medicine approaches.