Nifuratel (CAS 4936-47-4)

Nifuratel, with the CAS number 4936-47-4, is a nitrofuran derivative recognized for its broad antimicrobial properties, targeting a variety of pathogens including bacteria, fungi, and protozoa. The compound′s mechanism of action is primarily attributed to its ability to disrupt the enzymatic activities within microbial cells. Nifuratel is believed to exert its effect by undergoing reduction within the target cells, leading to the formation of reactive intermediates. These intermediates then interact with cellular components such as DNA, proteins, and respiratory enzymes, inducing structural damage and inhibiting critical metabolic pathways. Particularly, the interaction with DNA is believed to involve the modification of nucleic acids, which disrupts DNA synthesis and leads to cell death. In research contexts, nifuratel has been employed in studies exploring the efficacy of antimicrobial agents against a spectrum of organisms, especially those resistant to common treatments. It serves as a model compound in the study of nitrofuran-based antimicrobial activity, providing insights into the mechanisms by which such compounds can overcome resistance. Additionally, research involving nifuratel has contributed to understanding the metabolic pathways of microbial resistance and adaptation, aiding in the development of strategies to counteract microbial proliferation in various environmental contexts. This has implications for improving sanitation and combating microbial contamination in diverse settings.