Molecular structure of Nifekalant Hydrochloride, CAS Number: 130656-51-8
Nifekalant Hydrochloride (CAS 130656-51-8)
Alternate Names:
MS 551
Application:
Nifekalant Hydrochloride is an antiarrhythmic HERG inhibitor
CAS Number:
130656-51-8
Purity:
≥99%
Molecular Weight:
441.91
Molecular Formula:
C19H27N5O5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Nifekalant Hydrochloride is an antiarrhythmic shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage- and frequency-dependent manner.
Nifekalant Hydrochloride (CAS 130656-51-8) References
- Antiarrhythmic effect of nifekalant on atrial tachyarrhythmia in four patients with severe heart failure. | Shiga, T., et al. 2002. J Cardiol. 39: 159-64. PMID: 11912950
- Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardia. | Igawa, M., et al. 2002. J Cardiovasc Pharmacol. 40: 735-42. PMID: 12409982
- Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action. | Kushida, S., et al. 2002. Eur J Pharmacol. 457: 19-27. PMID: 12460639
- Nifekalant hydrochloride suppresses severe electrical storm in patients with malignant ventricular tachyarrhythmias. | Washizuka, T., et al. 2005. Circ J. 69: 1508-13. PMID: 16308500
- Nifekalant hydrochloride administration during cardiopulmonary resuscitation improves the transmural dispersion of myocardial repolarization: experimental study in a canine model of cardiopulmonary arrest. | Yoshioka, K., et al. 2006. Circ J. 70: 1200-7. PMID: 16936437
- Nifekalant hydrochloride terminated electrical storms after coronary surgery. | Kurisu, K., et al. 2010. Ann Thorac Surg. 89: 1637-9. PMID: 20417798
- Nifekalant hydrochloride terminating sustained ventricular tachycardia accompanied with QT dispersion prolongation. | Wang, J., et al. 2010. Chin Med J (Engl). 123: 2028-33. PMID: 20819537
- Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. | Pantazopoulos, IN., et al. 2011. World J Cardiol. 3: 169-76. PMID: 21772943
- An HPLC method for the determination of nifekalant hydrochloride in canine plasma and its application to a pharmacokinetic study. | Zhou, Y., et al. 2013. J Chromatogr Sci. 51: 867-71. PMID: 23169932
- Atrial pacing and administration of nifekalant hydrochloride for unstable atrial fibrillation: a case report. | Yakabe, D., et al. 2020. Eur Heart J Case Rep. 4: 1-5. PMID: 32617511
Inhibitor of:
HERG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nifekalant Hydrochloride, 10 mg | sc-204819 | 10 mg | $112.00 | |||
Nifekalant Hydrochloride, 25 mg | sc-204819A | 25 mg | $225.00 |