Molecular structure of Nifedipine-d6, CAS Number: 1188266-14-9
Nifedipine-d6 (CAS 1188266-14-9)
Alternate Names:
Adalate-d6; Aldipine-d6; Anifed-d6; Cardiate-d6
Application:
Nifedipine-d6 is an isotopically labeled Ca channel blocker
CAS Number:
1188266-14-9
Molecular Weight:
352.37
Molecular Formula:
C17H12D6N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nifedipine-d6 is utilized as an internal standard in analytical chemistry to ensure the accuracy and precision of measurements, particularly in the quantification of nifedipine in various samples using techniques like mass spectrometry or chromatography. Its role revolves around its stability and reliability in experimental applications due to the incorporation of deuterium atoms, which are heavier isotopes of hydrogen. This modification minimizes the exchange reactions and reduces the degradation, making Nifedipine-d6 excellent for studying the kinetics and metabolic pathways of nifedipine without interference from varying environmental conditions.
Nifedipine-d6 (CAS 1188266-14-9) References
- Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study. | Wang, XD., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 852: 534-44. PMID: 17339138
- Highly sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nifedipine in human plasma and its application to a bioequivalence study. | Patel, DP., et al. 2012. Biomed Chromatogr. 26: 1509-18. PMID: 22383257
- Quantification of 21 antihypertensive drugs in serum using UHPLC-MS/MS. | Gundersen, POM., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1089: 84-93. PMID: 29783197
- Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors. | Zhu, YT., et al. 2020. Drug Des Devel Ther. 14: 1963-1970. PMID: 32546963
- IP3R1 regulates Ca2+ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury. | Mo, G., et al. 2021. Cell Death Discov. 7: 31. PMID: 33568649
- Raman Mapping-Based Reverse Engineering Facilitates Development of Sustained-Release Nifedipine Tablet. | Sun, N., et al. 2022. Pharmaceutics. 14: PMID: 35631638
- Pharmacokinetics and Bioequivalence of 2 Nifedipine Controlled-Release Tablets: A Randomized, Single-Dose, 2-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions. | Xin, L., et al. 2023. Clin Pharmacol Drug Dev.. PMID: 37132398
- Pharmacokinetics of Nifedipine-Sustained Release Tablets in Healthy Subjects After a Single Oral Administration: Bioequivalence Analysis and Food Effects. | Wu, YX., et al. 2023. Clin Pharmacol Drug Dev.. PMID: 37243536
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nifedipine-d6, 1 mg | sc-219373 | 1 mg | $306.00 |