Molecular structure of NIDA-41020, CAS Number: 502486-89-7
NIDA-41020 (CAS 502486-89-7)
Alternate Names:
1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
Application:
NIDA-41020 is a CB1 cannabinoid receptor antagonist
CAS Number:
502486-89-7
Purity:
≥98%
Molecular Weight:
459.37
Molecular Formula:
C23H24Cl2N4O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].
NIDA-41020 (CAS 502486-89-7) References
1.Lange, J.H.M. and Kruse, C.G., Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists Drug Discov. Today 10, 693-702, (2005) Katoch-Rouse, R., et al., Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity J. Med. Chem. 46, 642-645, (2003)Inhibitor of:
CB1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NIDA-41020, 10 mg | sc-253189 | 10 mg | $185.00 |