Nicotinic Acid N-Hydroxysuccinimide Ester (CAS 78348-28-4)

Nicotinic acid N-hydroxysuccinimide ester (NHS-NA) serves as a versatile compound with diverse applications in scientific research, spanning synthetic chemistry to biomedical investigations. Derived from nicotinic acid, an essential nutrient for humans, Nicotinic acid N-hydroxysuccinimide ester finds widespread use in bioconjugation and various chemical processes due to its exceptional capability to form robust covalent bonds with a broad range of molecules. Within scientific research, Nicotinic acid N-hydroxysuccinimide ester holds a pivotal role in bioconjugation, surface modification, and drug delivery. It enables the attachment of molecules to proteins, peptides, and other biomolecules, facilitating the creation of targeted drug delivery systems and deepening the understanding of protein structure and function. Furthermore, Nicotinic acid N-hydroxysuccinimide ester contributes to surface modifications, enhancing the biocompatibility of medical implants. Additionally, Nicotinic acid N-hydroxysuccinimide ester finds application in drug delivery systems by enabling the attachment of therapeutic agents to carriers such as polymers and liposomes. The strong covalent bonds formed by Nicotinic acid N-hydroxysuccinimide ester extend to a variety of molecules, including proteins, peptides, and other biomolecules. This bonding process involves the formation of a Schiff base, which is an amide linkage. By deprotonating the carboxylic acid group of Nicotinic acid N-hydroxysuccinimide ester, followed by the formation of a Schiff base with the amine group of the targeted molecule, robust covalent bonds are established. The reversibility of this reaction enables the creation of enduring covalent bonds between molecules, underscoring the versatility and efficacy of Nicotinic acid N-hydroxysuccinimide ester in scientific research.