Molecular structure of Nicotinic acid adenine dinucleotide phosphate sodium salt, CAS Number: 5502-96-5
Nicotinic acid adenine dinucleotide phosphate sodium salt (CAS 5502-96-5)
Alternate Names:
NAADP tetrasodium salt; β-NAADP
Application:
Nicotinic acid adenine dinucleotide phosphate sodium salt is a potent activator of intracellular Ca2+ mobilzation
CAS Number:
5502-96-5
Purity:
≥92%
Molecular Weight:
832.32
Molecular Formula:
C21H23N6Na4O18P3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nicotinic acid adenine dinucleotide phosphate sodium salt (NAADP) initiates intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. The structure of Nicotinic acid adenine dinucleotide phosphate sodium salt is identical to that of its parent NADP, except that the amide nitrogen of the nicotinamide group of NADP is changed to oxygen.The actual Ca2+ release channels targeted by Nicotinic acid adenine dinucleotide phosphate sodium salt have recently been identified as the lysosomal two-pore channels (TPCs). Thus, cellular response to Nicotinic acid adenine dinucleotide phosphate sodium salt can be enhanced by overexpression of TPC and reduced by channel knockdown.
Nicotinic acid adenine dinucleotide phosphate sodium salt (CAS 5502-96-5) References
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- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells. | Arredouani, A., et al. 2015. J Biol Chem. 290: 21376-92. PMID: 26152717
- Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells. | Ali, RA., et al. 2016. J Biol Chem. 291: 4503-22. PMID: 26728458
- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. | Gul, R., et al. 2016. PLoS One. 11: e0149125. PMID: 26959359
- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells. | Faris, P., et al. 2019. Cancers (Basel). 11: PMID: 30991693
- Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+ release in endothelial colony-forming cells. | Moccia, F., et al. 2021. J Cell Physiol. 236: 688-705. PMID: 32583526
- Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells. | Faris, P., et al. 2022. Front Cell Dev Biol. 10: 874043. PMID: 35392169
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- A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. | Lee, HC. and Aarhus, R. 1995. J Biol Chem. 270: 2152-7. PMID: 7836444
- Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs. | Chini, EN., et al. 1995. J Biol Chem. 270: 3216-23. PMID: 7852407
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic acid adenine dinucleotide phosphate sodium salt, 10 mg | sc-215564 | 10 mg | $481.00 | |||
Nicotinic acid adenine dinucleotide phosphate sodium salt, 25 mg | sc-215564A | 25 mg | $995.00 |